tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2025 Sep 1.
doi: 10.1097/INF.0000000000004964. Online ahead of print. Measuring High-sensitive Cardiac Troponin Concentrations Predicted Hospital Deaths in Children With Severe Coronavirus Disease 2019
Yan Li[SUP] 1 [/SUP], Aiqin Song[SUP] 1 [/SUP], Sainan Sun[SUP] 1 2 [/SUP], Zhenmei Lv[SUP] 1 [/SUP], Jiye Song[SUP] 1 [/SUP], Yingtao Zhang[SUP] 3 [/SUP], Yongwen Huang[SUP] 4 [/SUP], Huabing Li[SUP] 5 [/SUP], Zhili Guo[SUP] 6 [/SUP], Lixiang Wang[SUP] 4 [/SUP], Kequan Li[SUP] 7 [/SUP], Caixia Wang[SUP] 8 [/SUP], Xianwei Liu[SUP] 9 [/SUP], Xuemei Wang[SUP] 4 [/SUP], Hua Pan[SUP] 1 [/SUP]
Affiliations
Background: Antiviral drugs and coronavirus disease 2019 (COVID-19) vaccines have significantly reduced COVID-19-related hospitalizations and deaths in infected children. However, COVID-19 continues to pose a major mortality risk in young children. High-sensitive cardiac troponin (Hs-cTn) is a specific marker of myocardial cell damage. After infection with the novel coronavirus, myocardial cells are damaged, and high-sensitive troponin will increase. In this study, we aimed to evaluate the predictive power of hs-cTnT for in-hospital mortality in pediatric COVID-19 patients.
Methods: In this study, which was conducted between December 2021 and January 2022, we included severely ill pediatric COVID-19 patients. We recorded their clinical data. Then, the association of hs-cTnT levels with mortality and of alanine aminotransferase and creatinine levels with mortality was analyzed.
Results: For the 119 children (70 males and 49 females) with severe COVID-19 included, the findings of univariate and multivariable Cox regression analyses revealed a significant association between hs-cTnT and in-hospital mortality (hazard ratio: 14.835; 95% confidence interval: 6.051-36.373; P < 0.001). The cutoff level of hs-cTnT to accurately predict in-hospital mortality was 0.09 ng/mL (area under the curve: 0.989; sensitivity: 1.000; specificity: 0.961; Youden index: 0.961).
Conclusion: In severely ill children with COVID-19 infection, hs-cTnT can be used as an independent biomarker to predict in-hospital mortality. The optimum cutoff was 0.09 ng/mL.
Keywords: COVID-19; death rate; myocardial injury; troponin.
. 2025 Sep 1.
doi: 10.1097/INF.0000000000004964. Online ahead of print. Measuring High-sensitive Cardiac Troponin Concentrations Predicted Hospital Deaths in Children With Severe Coronavirus Disease 2019
Yan Li[SUP] 1 [/SUP], Aiqin Song[SUP] 1 [/SUP], Sainan Sun[SUP] 1 2 [/SUP], Zhenmei Lv[SUP] 1 [/SUP], Jiye Song[SUP] 1 [/SUP], Yingtao Zhang[SUP] 3 [/SUP], Yongwen Huang[SUP] 4 [/SUP], Huabing Li[SUP] 5 [/SUP], Zhili Guo[SUP] 6 [/SUP], Lixiang Wang[SUP] 4 [/SUP], Kequan Li[SUP] 7 [/SUP], Caixia Wang[SUP] 8 [/SUP], Xianwei Liu[SUP] 9 [/SUP], Xuemei Wang[SUP] 4 [/SUP], Hua Pan[SUP] 1 [/SUP]
Affiliations
- PMID: 40924684
- DOI: 10.1097/INF.0000000000004964
Background: Antiviral drugs and coronavirus disease 2019 (COVID-19) vaccines have significantly reduced COVID-19-related hospitalizations and deaths in infected children. However, COVID-19 continues to pose a major mortality risk in young children. High-sensitive cardiac troponin (Hs-cTn) is a specific marker of myocardial cell damage. After infection with the novel coronavirus, myocardial cells are damaged, and high-sensitive troponin will increase. In this study, we aimed to evaluate the predictive power of hs-cTnT for in-hospital mortality in pediatric COVID-19 patients.
Methods: In this study, which was conducted between December 2021 and January 2022, we included severely ill pediatric COVID-19 patients. We recorded their clinical data. Then, the association of hs-cTnT levels with mortality and of alanine aminotransferase and creatinine levels with mortality was analyzed.
Results: For the 119 children (70 males and 49 females) with severe COVID-19 included, the findings of univariate and multivariable Cox regression analyses revealed a significant association between hs-cTnT and in-hospital mortality (hazard ratio: 14.835; 95% confidence interval: 6.051-36.373; P < 0.001). The cutoff level of hs-cTnT to accurately predict in-hospital mortality was 0.09 ng/mL (area under the curve: 0.989; sensitivity: 1.000; specificity: 0.961; Youden index: 0.961).
Conclusion: In severely ill children with COVID-19 infection, hs-cTnT can be used as an independent biomarker to predict in-hospital mortality. The optimum cutoff was 0.09 ng/mL.
Keywords: COVID-19; death rate; myocardial injury; troponin.