tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2022 Dec 12.
doi: 10.1097/INF.0000000000003802. Online ahead of print.
Maternal, Infant, and Breast Milk Antibody Response Following COVID-19 Infection in Early Versus Late Gestation
Elisha M Wachman[SUP] 1 [/SUP], Jennifer Snyder-Cappione[SUP] 2 [/SUP], Jean Devera[SUP] 3 [/SUP], Jeffery Boateng[SUP] 1 [/SUP], Yashoda Dhole[SUP] 3 [/SUP], Katherine Clarke[SUP] 2 [/SUP], Rachel R Yuen[SUP] 2 [/SUP], Samantha E Parker[SUP] 4 [/SUP], Jessica Hunnewell[SUP] 4 [/SUP], Renee Ferraro[SUP] 1 [/SUP], Sigride Jean-Sicard[SUP] 1 [/SUP], Elizabeth Woodard[SUP] 1 [/SUP], Alice Cruikshank[SUP] 1 [/SUP], Bharati Sinha[SUP] 1 [/SUP], Ruby Bartolome[SUP] 1 [/SUP], Elizabeth D Barnett[SUP] 1 [/SUP], Christina Yarrington[SUP] 5 [/SUP], Elizabeth S Taglauer[SUP] 1 [/SUP], Vishakha Sabharwal[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] infection at varying time points during the pregnancy can influence antibody levels after delivery. We aimed to examine SARS-CoV-2 IgG, IgM and IgA receptor binding domain of the spike protein and nucleocapsid protein (N-protein) reactive antibody concentrations in maternal blood, infant blood and breastmilk at birth and 6 weeks after SARS-CoV-2 infection in early versus late gestation.
Methods: Mothers with SARS-CoV-2 infection during pregnancy were enrolled between July 2020 and May 2021. Maternal blood, infant blood and breast milk samples were collected at delivery and 6 weeks postpartum. Samples were analyzed for SARS-CoV-2 spike and N-protein reactive IgG, IgM and IgA antibodies. Antibody concentrations were compared at the 2 time points and based on trimester of infection ("early" 1st/2nd vs. "late" 3rd).
Results: Dyads from 20 early and 11 late trimester infections were analyzed. For the entire cohort, there were no significant differences in antibody levels at delivery versus 6 weeks with the exception of breast milk levels which declined over time. Early gestation infections were associated with higher levels of breastmilk IgA to spike protein (P = 0.04). Infant IgG levels to spike protein were higher at 6 weeks after late infections (P = 0.04). There were strong correlations between maternal and infant IgG levels at delivery (P < 0.01), and between breastmilk and infant IgG levels.
Conclusions: SARS-CoV-2 infection in early versus late gestation leads to a persistent antibody response in maternal blood, infant blood and breast milk over the first 6 weeks after delivery.
. 2022 Dec 12.
doi: 10.1097/INF.0000000000003802. Online ahead of print.
Maternal, Infant, and Breast Milk Antibody Response Following COVID-19 Infection in Early Versus Late Gestation
Elisha M Wachman[SUP] 1 [/SUP], Jennifer Snyder-Cappione[SUP] 2 [/SUP], Jean Devera[SUP] 3 [/SUP], Jeffery Boateng[SUP] 1 [/SUP], Yashoda Dhole[SUP] 3 [/SUP], Katherine Clarke[SUP] 2 [/SUP], Rachel R Yuen[SUP] 2 [/SUP], Samantha E Parker[SUP] 4 [/SUP], Jessica Hunnewell[SUP] 4 [/SUP], Renee Ferraro[SUP] 1 [/SUP], Sigride Jean-Sicard[SUP] 1 [/SUP], Elizabeth Woodard[SUP] 1 [/SUP], Alice Cruikshank[SUP] 1 [/SUP], Bharati Sinha[SUP] 1 [/SUP], Ruby Bartolome[SUP] 1 [/SUP], Elizabeth D Barnett[SUP] 1 [/SUP], Christina Yarrington[SUP] 5 [/SUP], Elizabeth S Taglauer[SUP] 1 [/SUP], Vishakha Sabharwal[SUP] 1 [/SUP]
Affiliations
- PMID: 36729773
- DOI: 10.1097/INF.0000000000003802
Abstract
Background: Coronavirus disease 2019 [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] infection at varying time points during the pregnancy can influence antibody levels after delivery. We aimed to examine SARS-CoV-2 IgG, IgM and IgA receptor binding domain of the spike protein and nucleocapsid protein (N-protein) reactive antibody concentrations in maternal blood, infant blood and breastmilk at birth and 6 weeks after SARS-CoV-2 infection in early versus late gestation.
Methods: Mothers with SARS-CoV-2 infection during pregnancy were enrolled between July 2020 and May 2021. Maternal blood, infant blood and breast milk samples were collected at delivery and 6 weeks postpartum. Samples were analyzed for SARS-CoV-2 spike and N-protein reactive IgG, IgM and IgA antibodies. Antibody concentrations were compared at the 2 time points and based on trimester of infection ("early" 1st/2nd vs. "late" 3rd).
Results: Dyads from 20 early and 11 late trimester infections were analyzed. For the entire cohort, there were no significant differences in antibody levels at delivery versus 6 weeks with the exception of breast milk levels which declined over time. Early gestation infections were associated with higher levels of breastmilk IgA to spike protein (P = 0.04). Infant IgG levels to spike protein were higher at 6 weeks after late infections (P = 0.04). There were strong correlations between maternal and infant IgG levels at delivery (P < 0.01), and between breastmilk and infant IgG levels.
Conclusions: SARS-CoV-2 infection in early versus late gestation leads to a persistent antibody response in maternal blood, infant blood and breast milk over the first 6 weeks after delivery.