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Pediatr Infect Dis J . Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates

tetano

Editor, Senior Moderator
Pediatr Infect Dis J


. 2024 Jul 31.
doi: 10.1097/INF.0000000000004501. Online ahead of print. Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates

Jennie Godwin[SUP] 1 [/SUP], John Daniel 4th, Susana Chavez-Bueno, Venkatesh Sampath



Affiliations
Abstract

The genetic basis of neonatal COVID-19 infection, which exhibits a range of severity, has not been investigated. We identified both shared and unique genetic variants involved in antiviral immune responses through whole exome sequencing of an infant who developed severe COVID-19 pneumonia and multisystem inflammatory syndrome and the twin brother also positive for severe acute respiratory syndrome-coronavirus-2, but with only moderate respiratory symptoms.


 
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