tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2026 Feb 26.
doi: 10.1097/INF.0000000000005192. Online ahead of print.
Impaired Treg Response and Subclinical Cardiac Dysfunction in Children Following SARS-CoV-2 Infection
Costanza Di Chiara[SUP] 1 2 3 [/SUP], Anna Cantarutti[SUP] 4 [/SUP], Jolanda Sabatino[SUP] 5 [/SUP], Domenico Sirico[SUP] 1 [/SUP], Francesco Bonfante[SUP] 6 [/SUP], Marthe Le Prevost[SUP] 2 7 [/SUP], Danilo Buonsenso[SUP] 8 9 [/SUP], Emma Concetta Manno[SUP] 10 [/SUP], Francesco Carmona[SUP] 11 [/SUP], Daniele Donà[SUP] 1 2 [/SUP], Anita De Rossi[SUP] 12 [/SUP], Giovanni Di Salvo[SUP] 1 [/SUP], Maria Raffaella Petrara[SUP] 11 [/SUP], Carlo Giaquinto[SUP] 1 2 [/SUP]
Affiliations
In a preliminary cohort of children recovering from asymptomatic or mild coronavirus disease 2019, subclinical cardiac contractility alterations were associated with reduced regulatory T cells, shorter telomeres and elevated inflammatory markers 3 months post-infection. These findings suggest that immune dysregulation may contribute to silent post-coronavirus disease 2019 cardiac dysfunction and warrant confirmation in larger cohorts with long-term follow-up.
Keywords: cardiac contractility alterations; children; immune profile; post-COVID; speckle-tracking echocardiography.
. 2026 Feb 26.
doi: 10.1097/INF.0000000000005192. Online ahead of print.
Impaired Treg Response and Subclinical Cardiac Dysfunction in Children Following SARS-CoV-2 Infection
Costanza Di Chiara[SUP] 1 2 3 [/SUP], Anna Cantarutti[SUP] 4 [/SUP], Jolanda Sabatino[SUP] 5 [/SUP], Domenico Sirico[SUP] 1 [/SUP], Francesco Bonfante[SUP] 6 [/SUP], Marthe Le Prevost[SUP] 2 7 [/SUP], Danilo Buonsenso[SUP] 8 9 [/SUP], Emma Concetta Manno[SUP] 10 [/SUP], Francesco Carmona[SUP] 11 [/SUP], Daniele Donà[SUP] 1 2 [/SUP], Anita De Rossi[SUP] 12 [/SUP], Giovanni Di Salvo[SUP] 1 [/SUP], Maria Raffaella Petrara[SUP] 11 [/SUP], Carlo Giaquinto[SUP] 1 2 [/SUP]
Affiliations
- PMID: 41742349
- DOI: 10.1097/INF.0000000000005192
In a preliminary cohort of children recovering from asymptomatic or mild coronavirus disease 2019, subclinical cardiac contractility alterations were associated with reduced regulatory T cells, shorter telomeres and elevated inflammatory markers 3 months post-infection. These findings suggest that immune dysregulation may contribute to silent post-coronavirus disease 2019 cardiac dysfunction and warrant confirmation in larger cohorts with long-term follow-up.
Keywords: cardiac contractility alterations; children; immune profile; post-COVID; speckle-tracking echocardiography.