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Pediatr Infect Dis J . Antibody Seronegativity in COVID-19 RT-PCR-Positive Children

tetano

Editor, Senior Moderator
Pediatr Infect Dis J


. 2022 May 9.
doi: 10.1097/INF.0000000000003573. Online ahead of print.
Antibody Seronegativity in COVID-19 RT-PCR-Positive Children


Maala Bhatt[SUP] 1 [/SUP], Roger L Zemek[SUP] 1 [/SUP], Ken Tang[SUP] 2 [/SUP], Richard Malley[SUP] 3 [/SUP], Amy C Plint[SUP] 1 [/SUP], Anne Pham-Huy[SUP] 1 [/SUP], Jennifer Dawson[SUP] 2 [/SUP], Candice McGahern[SUP] 2 [/SUP], Martin Pelchat[SUP] 4 [/SUP], Corey Arnold[SUP] 4 [/SUP], Yannick Galipeau[SUP] 4 [/SUP], Marc-André Langlois[SUP] 4 [/SUP]



Affiliations

Abstract

This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction-positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Apart from the absence of fever/chills, individual symptoms did not strongly predict nonseroconversion.
 
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