tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2020 Oct;39(10):e297-e302.
doi: 10.1097/INF.0000000000002862.
A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19
Mehmet Kenan Kanburoglu[SUP] 1 [/SUP], Cuneyt Tayman[SUP] 2 [/SUP], Mehmet Yekta Oncel[SUP] 3 4 [/SUP], Ilke Mungan Akin[SUP] 5 [/SUP], Emrah Can[SUP] 6 [/SUP], Nihat Demir[SUP] 7 [/SUP], Sema Arayici[SUP] 8 [/SUP], Demet Orhan Baser[SUP] 9 [/SUP], Ibrahim Caner[SUP] 10 [/SUP], Asli Memisoglu[SUP] 11 [/SUP], Saime Sundus Uygun[SUP] 12 [/SUP], Selahattin Akar[SUP] 13 [/SUP], Mustafa Ali Akin[SUP] 14 [/SUP], Emel Ataoglu[SUP] 15 [/SUP], Handan Bezirganoglu[SUP] 16 [/SUP], Leyla Bilgin[SUP] 17 [/SUP], Senol Bozdag[SUP] 18 [/SUP], Serdar Comert[SUP] 19 [/SUP], Resat Gurpinar[SUP] 20 [/SUP], Ebru Yalin Imamoglu[SUP] 21 [/SUP], Timucin Imdadoglu[SUP] 22 [/SUP], Fatma Narter[SUP] 23 [/SUP], Ramazan Ozdemir[SUP] 24 [/SUP], Handan Hakyemez Toptan[SUP] 25 [/SUP], Emine Esin Yalinbas[SUP] 26 [/SUP], Akan Yaman[SUP] 27 [/SUP], Omer Erdeve[SUP] 28 [/SUP], Esin Koc[SUP] 29 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19.
Methods: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded.
Results: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1-35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1-8.6] vs. 5.8 [0.3-69.2] p = 0.002, 11.9 [10.1-17.2] vs. 15.2 [11.7-18.0] p = 0.01, respectively) or who were severe/critical (1.0 [0.01-8.6] vs. 4.5 [0.1-69.2] p = 0.01, 11.7 [10.1-13.9] vs. 15.0 [11.7-18.0] p = 0.001, respectively).
Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.
. 2020 Oct;39(10):e297-e302.
doi: 10.1097/INF.0000000000002862.
A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19
Mehmet Kenan Kanburoglu[SUP] 1 [/SUP], Cuneyt Tayman[SUP] 2 [/SUP], Mehmet Yekta Oncel[SUP] 3 4 [/SUP], Ilke Mungan Akin[SUP] 5 [/SUP], Emrah Can[SUP] 6 [/SUP], Nihat Demir[SUP] 7 [/SUP], Sema Arayici[SUP] 8 [/SUP], Demet Orhan Baser[SUP] 9 [/SUP], Ibrahim Caner[SUP] 10 [/SUP], Asli Memisoglu[SUP] 11 [/SUP], Saime Sundus Uygun[SUP] 12 [/SUP], Selahattin Akar[SUP] 13 [/SUP], Mustafa Ali Akin[SUP] 14 [/SUP], Emel Ataoglu[SUP] 15 [/SUP], Handan Bezirganoglu[SUP] 16 [/SUP], Leyla Bilgin[SUP] 17 [/SUP], Senol Bozdag[SUP] 18 [/SUP], Serdar Comert[SUP] 19 [/SUP], Resat Gurpinar[SUP] 20 [/SUP], Ebru Yalin Imamoglu[SUP] 21 [/SUP], Timucin Imdadoglu[SUP] 22 [/SUP], Fatma Narter[SUP] 23 [/SUP], Ramazan Ozdemir[SUP] 24 [/SUP], Handan Hakyemez Toptan[SUP] 25 [/SUP], Emine Esin Yalinbas[SUP] 26 [/SUP], Akan Yaman[SUP] 27 [/SUP], Omer Erdeve[SUP] 28 [/SUP], Esin Koc[SUP] 29 [/SUP]
Affiliations
- PMID: 32932329
- DOI: 10.1097/INF.0000000000002862
Abstract
Background: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19.
Methods: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded.
Results: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1-35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1-8.6] vs. 5.8 [0.3-69.2] p = 0.002, 11.9 [10.1-17.2] vs. 15.2 [11.7-18.0] p = 0.01, respectively) or who were severe/critical (1.0 [0.01-8.6] vs. 4.5 [0.1-69.2] p = 0.01, 11.7 [10.1-13.9] vs. 15.0 [11.7-18.0] p = 0.001, respectively).
Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.