tetano
Editor, Senior Moderator
J Infect Dis. 2013 Jul 17. [Epub ahead of print]
Patients hospitalized with laboratory-confirmed influenza during the 2010-2011 influenza season: exploring disease severity by virus type and subtype.
Chaves SS, Aragon D, Bennett N, Cooper T, D'Mello T, Farley M, Fowler B, Hancock E, Kirley PD, Lynfield R, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Williams J, Yousey-Hindes K, Zansky S, Finelli L.
Source
Centers for Disease Control and Prevention, Atlanta, GA.
Abstract
Background. The 2010-11 influenza season was dominated by influenza A(H3N2) virus, but influenza A(H1N1)pdm09 (pH1N1) and B viruses co-circulated. This provided an opportunity to explore within-season predictors of severity among hospitalized patients, avoiding biases associated with season to season differences in strain virulence, population immunity and healthcare seeking.Methods. Population-based, laboratory-confirmed influenza hospitalization surveillance data were used to examine the association between virus type/subtype and outcomes in children and adults. Multivariable analysis explored virus type/subtype, prompt antiviral treatment, medical conditions, and age as predictors for severity (ICU admission or death).Results. In children, pH1N1 (adjusted odds ratio [aOR] 2.19; 95% CI 1.11-4.3), chronic metabolic disease (aOR 5.23; 95% CI 1.74-15.69) and neuromuscular disorder (aOR 4.84; 95% CI 2.02-11.58) were independently associated with severity. In adults, independent predictors were pH1N1 (aOR 2.21; 95% CI 1.66-2.94), chronic lung disease (aOR 1.46, 95% CI 1.12-1.89) and neuromuscular disorder (aOR 1.68; 95% CI 1.11-2.52). Antiviral treatment reduced the odds of severity among adults (aOR 0.47; 95% CI 0.33-0.68).Conclusions. During 2010-11 season, pH1N1 caused more severe disease than H3N2 or B in hospitalized patients. Underlying medical conditions increased severity despite virus strain. Antiviral treatment reduced severity among adults. Our findings underscore the importance of influenza prevention.
PMID:
23863950
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23863950
Patients hospitalized with laboratory-confirmed influenza during the 2010-2011 influenza season: exploring disease severity by virus type and subtype.
Chaves SS, Aragon D, Bennett N, Cooper T, D'Mello T, Farley M, Fowler B, Hancock E, Kirley PD, Lynfield R, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Williams J, Yousey-Hindes K, Zansky S, Finelli L.
Source
Centers for Disease Control and Prevention, Atlanta, GA.
Abstract
Background. The 2010-11 influenza season was dominated by influenza A(H3N2) virus, but influenza A(H1N1)pdm09 (pH1N1) and B viruses co-circulated. This provided an opportunity to explore within-season predictors of severity among hospitalized patients, avoiding biases associated with season to season differences in strain virulence, population immunity and healthcare seeking.Methods. Population-based, laboratory-confirmed influenza hospitalization surveillance data were used to examine the association between virus type/subtype and outcomes in children and adults. Multivariable analysis explored virus type/subtype, prompt antiviral treatment, medical conditions, and age as predictors for severity (ICU admission or death).Results. In children, pH1N1 (adjusted odds ratio [aOR] 2.19; 95% CI 1.11-4.3), chronic metabolic disease (aOR 5.23; 95% CI 1.74-15.69) and neuromuscular disorder (aOR 4.84; 95% CI 2.02-11.58) were independently associated with severity. In adults, independent predictors were pH1N1 (aOR 2.21; 95% CI 1.66-2.94), chronic lung disease (aOR 1.46, 95% CI 1.12-1.89) and neuromuscular disorder (aOR 1.68; 95% CI 1.11-2.52). Antiviral treatment reduced the odds of severity among adults (aOR 0.47; 95% CI 0.33-0.68).Conclusions. During 2010-11 season, pH1N1 caused more severe disease than H3N2 or B in hospitalized patients. Underlying medical conditions increased severity despite virus strain. Antiviral treatment reduced severity among adults. Our findings underscore the importance of influenza prevention.
PMID:
23863950
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23863950