tetano
Editor, Senior Moderator
Pathol Res Pract
. 2022 Mar 23;233:153848.
doi: 10.1016/j.prp.2022.153848. Online ahead of print.
The role of antigen-presenting cells in the pathogenesis of COVID-19
Rana Farzi[SUP] 1 [/SUP], Parisa Shiri Aghbash[SUP] 1 [/SUP], Narges Eslami[SUP] 2 [/SUP], Arezou Azadi[SUP] 3 [/SUP], Ali Shamekh[SUP] 4 [/SUP], Nima Hemmat[SUP] 5 [/SUP], Taher Entezari-Maleki[SUP] 6 [/SUP], Hossein Bannazadeh Baghi[SUP] 7 [/SUP]
Affiliations
Abstract
Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the so-called "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARS-CoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.
Keywords: Antigen Presenting Cell; B cells; COVID-19; DC; Macrophages; SARS-CoV-2.
. 2022 Mar 23;233:153848.
doi: 10.1016/j.prp.2022.153848. Online ahead of print.
The role of antigen-presenting cells in the pathogenesis of COVID-19
Rana Farzi[SUP] 1 [/SUP], Parisa Shiri Aghbash[SUP] 1 [/SUP], Narges Eslami[SUP] 2 [/SUP], Arezou Azadi[SUP] 3 [/SUP], Ali Shamekh[SUP] 4 [/SUP], Nima Hemmat[SUP] 5 [/SUP], Taher Entezari-Maleki[SUP] 6 [/SUP], Hossein Bannazadeh Baghi[SUP] 7 [/SUP]
Affiliations
- PMID: 35338971
- PMCID: PMC8941975
- DOI: 10.1016/j.prp.2022.153848
Abstract
Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the so-called "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARS-CoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.
Keywords: Antigen Presenting Cell; B cells; COVID-19; DC; Macrophages; SARS-CoV-2.