tetano
Editor, Senior Moderator
Pathol Res Pract
. 2022 Dec 31;242:154300.
doi: 10.1016/j.prp.2022.154300. Online ahead of print.
Granuloma annulare after SARS-CoV-2 vaccination: A case report and a literature review
Daniela Russo[SUP] 1 [/SUP], Rossella Accarino[SUP] 1 [/SUP], Silvia Varricchio[SUP] 2 [/SUP], Raduan Ahmed Franca[SUP] 1 [/SUP], Luca Potestio[SUP] 3 [/SUP], Cataldo Patruno[SUP] 4 [/SUP], Maddalena Napolitano[SUP] 5 [/SUP], Massimo Mascolo[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: During the Cov-19 pandemic, many studies reported a broad spectrum of cutaneous reactions presenting as erythematous rashes or pernio-like, urticaria-like or vesicular/bullous patterns associated with Cov-19-infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: The authors documented the clinical and histopathological features of an unexpected case of granuloma annulare (GA) arising a few days after the SARS-CoV-2 vaccination and reviewed all GAs reported in the literature following the SARS-CoV-2 vaccination and Cov-19-infection.
Case report: A 69-year-old woman developed a single reddish lesion on the left deltoid region, where the SARS-CoV-2 vaccine seven days earlier was injected. The clinicians performed a punch skin biopsy, and histology revealed an interstitial GA.
Conclusions: Clinicians should be aware of the potential, though rare, GA occurrence as a possible adverse event after the SARS-CoV-2 vaccination. This additional case, like what happens after the administration of other vaccines, supports the idea that GA may result from the immune system activation following the vaccination. However, notwithstanding, they should encourage their patients to obtain immunization to assist the public health systems in overcoming the COVID-19 pandemic.
Keywords: COVID-19 pandemic; Cutaneous reaction; Granuloma annulare; SARS-CoV-2 vaccination.
. 2022 Dec 31;242:154300.
doi: 10.1016/j.prp.2022.154300. Online ahead of print.
Granuloma annulare after SARS-CoV-2 vaccination: A case report and a literature review
Daniela Russo[SUP] 1 [/SUP], Rossella Accarino[SUP] 1 [/SUP], Silvia Varricchio[SUP] 2 [/SUP], Raduan Ahmed Franca[SUP] 1 [/SUP], Luca Potestio[SUP] 3 [/SUP], Cataldo Patruno[SUP] 4 [/SUP], Maddalena Napolitano[SUP] 5 [/SUP], Massimo Mascolo[SUP] 1 [/SUP]
Affiliations
- PMID: 36638589
- DOI: 10.1016/j.prp.2022.154300
Abstract
Introduction: During the Cov-19 pandemic, many studies reported a broad spectrum of cutaneous reactions presenting as erythematous rashes or pernio-like, urticaria-like or vesicular/bullous patterns associated with Cov-19-infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: The authors documented the clinical and histopathological features of an unexpected case of granuloma annulare (GA) arising a few days after the SARS-CoV-2 vaccination and reviewed all GAs reported in the literature following the SARS-CoV-2 vaccination and Cov-19-infection.
Case report: A 69-year-old woman developed a single reddish lesion on the left deltoid region, where the SARS-CoV-2 vaccine seven days earlier was injected. The clinicians performed a punch skin biopsy, and histology revealed an interstitial GA.
Conclusions: Clinicians should be aware of the potential, though rare, GA occurrence as a possible adverse event after the SARS-CoV-2 vaccination. This additional case, like what happens after the administration of other vaccines, supports the idea that GA may result from the immune system activation following the vaccination. However, notwithstanding, they should encourage their patients to obtain immunization to assist the public health systems in overcoming the COVID-19 pandemic.
Keywords: COVID-19 pandemic; Cutaneous reaction; Granuloma annulare; SARS-CoV-2 vaccination.