tetano
Editor, Senior Moderator
Pathol Int
. 2022 Dec 28.
doi: 10.1111/pin.13304. Online ahead of print.
Histopathological findings of pericarditis in a patient with multisystem inflammatory syndrome in children associated with COVID-19: A case report
Kazuaki Maruyama[SUP] 1 [/SUP], Kazushi Yasuda[SUP] 2 [/SUP], Ryoichi Ito[SUP] 2 [/SUP], Kyoko Imanaka-Yoshida[SUP] 1 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome in children (MIS-C), which is associated with the novel coronavirus disease 2019 (COVID-19), has been described as an inflammatory complication of exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It carries a risk of serious and lethal complications, including cardiogenic shock. Here, we report the pathological findings of the pericardium in a 10-year-old child with MIS-C, who developed pericarditis-induced cardiac tamponade. In the patient's pericardium, the numbers of infiltrating CD68[SUP]+[/SUP] macrophages; CD3[SUP]+[/SUP] , CD4[SUP]+[/SUP] , and CD8[SUP]+[/SUP] T cells; and myeloperoxidase[SUP]+[/SUP] granulocytes were increased, although the number of CD20[SUP]+[/SUP] B cells was not. These findings provide a clue to understanding the pathophysiology of MIS-C.
Keywords: MIS-C; SARS-CoV-2; cardiac tamponade; pericarditis.
. 2022 Dec 28.
doi: 10.1111/pin.13304. Online ahead of print.
Histopathological findings of pericarditis in a patient with multisystem inflammatory syndrome in children associated with COVID-19: A case report
Kazuaki Maruyama[SUP] 1 [/SUP], Kazushi Yasuda[SUP] 2 [/SUP], Ryoichi Ito[SUP] 2 [/SUP], Kyoko Imanaka-Yoshida[SUP] 1 [/SUP]
Affiliations
- PMID: 36575945
- DOI: 10.1111/pin.13304
Abstract
Multisystem inflammatory syndrome in children (MIS-C), which is associated with the novel coronavirus disease 2019 (COVID-19), has been described as an inflammatory complication of exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It carries a risk of serious and lethal complications, including cardiogenic shock. Here, we report the pathological findings of the pericardium in a 10-year-old child with MIS-C, who developed pericarditis-induced cardiac tamponade. In the patient's pericardium, the numbers of infiltrating CD68[SUP]+[/SUP] macrophages; CD3[SUP]+[/SUP] , CD4[SUP]+[/SUP] , and CD8[SUP]+[/SUP] T cells; and myeloperoxidase[SUP]+[/SUP] granulocytes were increased, although the number of CD20[SUP]+[/SUP] B cells was not. These findings provide a clue to understanding the pathophysiology of MIS-C.
Keywords: MIS-C; SARS-CoV-2; cardiac tamponade; pericarditis.