tetano
Editor, Senior Moderator
Pathogens
. 2021 May 18;10(5):621.
doi: 10.3390/pathogens10050621.
Serological Evidence of Backyard Pig Exposure to Highly Pathogenic Avian Influenza H5N8 Virus during 2016-2017 Epizootic in France
Séverine Hervé[SUP] 1 [/SUP], Audrey Schmitz[SUP] 2 [/SUP], François-Xavier Briand[SUP] 2 [/SUP], Stéphane Gorin[SUP] 1 [/SUP], Stéphane Quéguiner[SUP] 1 [/SUP], Éric Niqueux[SUP] 2 [/SUP], Frédéric Paboeuf[SUP] 3 [/SUP], Axelle Scoizec[SUP] 4 [/SUP], Sophie Le Bouquin-Leneveu[SUP] 4 [/SUP], Nicolas Eterradossi[SUP] 2 [/SUP], Gaëlle Simon[SUP] 1 [/SUP]
Affiliations
Abstract
In autumn/winter 2016-2017, HPAI-H5N8 viruses belonging to the A/goose/Guandong/1/1996 (Gs/Gd) lineage, clade 2.3.4.4b, were responsible for outbreaks in domestic poultry in Europe, and veterinarians were requested to reinforce surveillance of pigs bred in HPAI-H5Nx confirmed mixed herds. In this context, ten pig herds were visited in southwestern France from December 2016 to May 2017 and serological analyses for influenza A virus (IAV) infections were carried out by ELISA and hemagglutination inhibition assays. In one herd, one backyard pig was shown to have produced antibodies directed against a virus bearing a H5 from clade 2.3.4.4b, suggesting it would have been infected naturally after close contact with HPAI-H5N8 contaminated domestic ducks. Whereas pigs and other mammals, including humans, may have limited sensitivity to HPAI-H5 clade 2.3.4.4b, this information recalls the importance of implementing appropriate biosecurity measures in pig and poultry farms to avoid IAV interspecies transmission, a prerequisite for co-infections and subsequent emergence of new viral genotypes whose impact on both animal and human health cannot be predicted.
Keywords: hemagglutination inhibition test; influenza outbreak; mixed herd; poultry; swine.
. 2021 May 18;10(5):621.
doi: 10.3390/pathogens10050621.
Serological Evidence of Backyard Pig Exposure to Highly Pathogenic Avian Influenza H5N8 Virus during 2016-2017 Epizootic in France
Séverine Hervé[SUP] 1 [/SUP], Audrey Schmitz[SUP] 2 [/SUP], François-Xavier Briand[SUP] 2 [/SUP], Stéphane Gorin[SUP] 1 [/SUP], Stéphane Quéguiner[SUP] 1 [/SUP], Éric Niqueux[SUP] 2 [/SUP], Frédéric Paboeuf[SUP] 3 [/SUP], Axelle Scoizec[SUP] 4 [/SUP], Sophie Le Bouquin-Leneveu[SUP] 4 [/SUP], Nicolas Eterradossi[SUP] 2 [/SUP], Gaëlle Simon[SUP] 1 [/SUP]
Affiliations
- PMID: 34070190
- DOI: 10.3390/pathogens10050621
Abstract
In autumn/winter 2016-2017, HPAI-H5N8 viruses belonging to the A/goose/Guandong/1/1996 (Gs/Gd) lineage, clade 2.3.4.4b, were responsible for outbreaks in domestic poultry in Europe, and veterinarians were requested to reinforce surveillance of pigs bred in HPAI-H5Nx confirmed mixed herds. In this context, ten pig herds were visited in southwestern France from December 2016 to May 2017 and serological analyses for influenza A virus (IAV) infections were carried out by ELISA and hemagglutination inhibition assays. In one herd, one backyard pig was shown to have produced antibodies directed against a virus bearing a H5 from clade 2.3.4.4b, suggesting it would have been infected naturally after close contact with HPAI-H5N8 contaminated domestic ducks. Whereas pigs and other mammals, including humans, may have limited sensitivity to HPAI-H5 clade 2.3.4.4b, this information recalls the importance of implementing appropriate biosecurity measures in pig and poultry farms to avoid IAV interspecies transmission, a prerequisite for co-infections and subsequent emergence of new viral genotypes whose impact on both animal and human health cannot be predicted.
Keywords: hemagglutination inhibition test; influenza outbreak; mixed herd; poultry; swine.