tetano
Editor, Senior Moderator
Pathogens
. 2021 Jun 15;10(6):754.
doi: 10.3390/pathogens10060754.
Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device
Hiroko Inagaki[SUP] 1 [/SUP], Akatsuki Saito[SUP] 2 3 4 [/SUP], Chiho Kaneko[SUP] 4 [/SUP], Hironobu Sugiyama[SUP] 1 5 [/SUP], Tamaki Okabayashi[SUP] 2 3 4 [/SUP], Shouichi Fujimoto[SUP] 6 [/SUP]
Affiliations
Abstract
More than 1 year has passed since social activities have been restricted due to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More recently, novel SARS-CoV-2 variants have been spreading around the world, and there is growing concern that they may have higher transmissibility and that the protective efficacy of vaccines may be weaker against them. Immediate measures are needed to reduce human exposure to the virus. In this study, the antiviral efficacy of deep-ultraviolet light-emitting diode (DUV-LED) irradiation (280 ± 5 nm, 3.75 mW/cm[SUP]2[/SUP]) against three SARS-CoV-2 variants was evaluated. For the B.1.1.7, B.1.351, and P.1 variant strains, irradiation of the virus stocks for 1 s resulted in infectious titer reduction rates of 96.3%, 94.6%, and 91.9%, respectively, and with irradiation for 5 s, the rates increased to 99.9%, 99.9%, and 99.8%, respectively. We also tested the effect of pulsed DUV-LED irradiation (7.5 mW/cm[SUP]2[/SUP], duty rate: 50%, frequency: 1 kHz) under the same output conditions as for continuous irradiation and found that the antiviral efficacy of pulsed and continuous irradiation was the same. These findings suggest that by further developing and optimizing the DUV-LED device to increase its output, it may be possible to instantly inactivate SARS-CoV-2 with DUV-LED irradiation.
Keywords: COVID-19; SARS-CoV-2; UV-LED; variants; viral inactivation.
. 2021 Jun 15;10(6):754.
doi: 10.3390/pathogens10060754.
Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device
Hiroko Inagaki[SUP] 1 [/SUP], Akatsuki Saito[SUP] 2 3 4 [/SUP], Chiho Kaneko[SUP] 4 [/SUP], Hironobu Sugiyama[SUP] 1 5 [/SUP], Tamaki Okabayashi[SUP] 2 3 4 [/SUP], Shouichi Fujimoto[SUP] 6 [/SUP]
Affiliations
- PMID: 34203643
- DOI: 10.3390/pathogens10060754
Abstract
More than 1 year has passed since social activities have been restricted due to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More recently, novel SARS-CoV-2 variants have been spreading around the world, and there is growing concern that they may have higher transmissibility and that the protective efficacy of vaccines may be weaker against them. Immediate measures are needed to reduce human exposure to the virus. In this study, the antiviral efficacy of deep-ultraviolet light-emitting diode (DUV-LED) irradiation (280 ± 5 nm, 3.75 mW/cm[SUP]2[/SUP]) against three SARS-CoV-2 variants was evaluated. For the B.1.1.7, B.1.351, and P.1 variant strains, irradiation of the virus stocks for 1 s resulted in infectious titer reduction rates of 96.3%, 94.6%, and 91.9%, respectively, and with irradiation for 5 s, the rates increased to 99.9%, 99.9%, and 99.8%, respectively. We also tested the effect of pulsed DUV-LED irradiation (7.5 mW/cm[SUP]2[/SUP], duty rate: 50%, frequency: 1 kHz) under the same output conditions as for continuous irradiation and found that the antiviral efficacy of pulsed and continuous irradiation was the same. These findings suggest that by further developing and optimizing the DUV-LED device to increase its output, it may be possible to instantly inactivate SARS-CoV-2 with DUV-LED irradiation.
Keywords: COVID-19; SARS-CoV-2; UV-LED; variants; viral inactivation.