tetano
Editor, Senior Moderator
Pathogens
. 2023 Feb 11;12(2):301.
doi: 10.3390/pathogens12020301.
Employing T-Cell Memory to Effectively Target SARS-CoV-2
Zaw Htet Tun[SUP] 1 [/SUP], Nang Thinn Thinn Htike[SUP] 1 [/SUP], Chaw Kyi-Tha-Thu[SUP] 2 [/SUP], Wing-Hin Lee[SUP] 3 [/SUP]
Affiliations
Abstract
Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases have encountered T-cell abnormalities. The emergence of several mutant strains has even threatened the effectiveness of the T-cell immunity that was established with the first-generation vaccines. Currently, the development of next-generation vaccines involves trying several approaches to educate T-cell memory to trigger a broad and fast response that targets several viral proteins. As the shaping of T-cell immunity in its fast and efficient form becomes important, this review discusses several interesting vaccine approaches to effectively employ T-cell memory for efficient viral containment. In addition, some essential facts and future possible consequences of using current vaccines are also highlighted.
Keywords: COVID-19; SARS-CoV-2; T cells; lung TRM; vaccine.
. 2023 Feb 11;12(2):301.
doi: 10.3390/pathogens12020301.
Employing T-Cell Memory to Effectively Target SARS-CoV-2
Zaw Htet Tun[SUP] 1 [/SUP], Nang Thinn Thinn Htike[SUP] 1 [/SUP], Chaw Kyi-Tha-Thu[SUP] 2 [/SUP], Wing-Hin Lee[SUP] 3 [/SUP]
Affiliations
- PMID: 36839573
- DOI: 10.3390/pathogens12020301
Abstract
Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases have encountered T-cell abnormalities. The emergence of several mutant strains has even threatened the effectiveness of the T-cell immunity that was established with the first-generation vaccines. Currently, the development of next-generation vaccines involves trying several approaches to educate T-cell memory to trigger a broad and fast response that targets several viral proteins. As the shaping of T-cell immunity in its fast and efficient form becomes important, this review discusses several interesting vaccine approaches to effectively employ T-cell memory for efficient viral containment. In addition, some essential facts and future possible consequences of using current vaccines are also highlighted.
Keywords: COVID-19; SARS-CoV-2; T cells; lung TRM; vaccine.