tetano
Editor, Senior Moderator
Avian Pathol. 2016 Jan 26:1-11. [Epub ahead of print]
[h=1]Pathogenicity of the Korean H5N8 highly pathogenic avian influenza virus in commercial domestic poultry species.[/h] Lee DH[SUP]1[/SUP], Kwon JH[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Park JK[SUP]1[/SUP], Yuk SS[SUP]1[/SUP], Erdene-Ochir TO[SUP]1[/SUP], Lee JB[SUP]1[/SUP], Park SY[SUP]1[/SUP], Choi IS[SUP]1[/SUP], Lee SW[SUP]1[/SUP], Song CS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In 2014, the highly pathogenic avian influenza (HPAI) virus H5N8 triggered outbreaks in wild birds and poultry farms in South Korea. In the present study, we investigated the pathogenicity of the H5N8 HPAI virus, belonging to the clade 2.3.4.4, in different species of poultry. Toward this, we examined clinical symptoms and viral shedding levels following intranasal inoculation of the virus in three-week-old commercial layer chickens and quails, 10-week-old Korean native chickens, and eight-week-old Muscovy ducks. Intranasal inoculation with 10[SUP]6.0[/SUP] viruses at 50% egg infective dose resulted in 100% mortality in the layer chickens (8/8) and quails (4/4), but 60% and 0% deaths in the Korean native chickens (3/5) and Muscovy ducks (0/4), respectively. In addition, transmission of the inoculated virus to contact-exposed birds was evident in all the species used in this study. Based on our results, we conclude that the H5N8 HPAI virus has lower pathogenicity and transmissibility in poultry species compared with previously reported H5N1 HPAI viruses.
[h=4]KEYWORDS:[/h] Avian influenza; H5N8; HPAI; Korea; pathogenicity; poultry
PMID: 26814367 [PubMed - as supplied by publisher]
[h=1]Pathogenicity of the Korean H5N8 highly pathogenic avian influenza virus in commercial domestic poultry species.[/h] Lee DH[SUP]1[/SUP], Kwon JH[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Park JK[SUP]1[/SUP], Yuk SS[SUP]1[/SUP], Erdene-Ochir TO[SUP]1[/SUP], Lee JB[SUP]1[/SUP], Park SY[SUP]1[/SUP], Choi IS[SUP]1[/SUP], Lee SW[SUP]1[/SUP], Song CS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In 2014, the highly pathogenic avian influenza (HPAI) virus H5N8 triggered outbreaks in wild birds and poultry farms in South Korea. In the present study, we investigated the pathogenicity of the H5N8 HPAI virus, belonging to the clade 2.3.4.4, in different species of poultry. Toward this, we examined clinical symptoms and viral shedding levels following intranasal inoculation of the virus in three-week-old commercial layer chickens and quails, 10-week-old Korean native chickens, and eight-week-old Muscovy ducks. Intranasal inoculation with 10[SUP]6.0[/SUP] viruses at 50% egg infective dose resulted in 100% mortality in the layer chickens (8/8) and quails (4/4), but 60% and 0% deaths in the Korean native chickens (3/5) and Muscovy ducks (0/4), respectively. In addition, transmission of the inoculated virus to contact-exposed birds was evident in all the species used in this study. Based on our results, we conclude that the H5N8 HPAI virus has lower pathogenicity and transmissibility in poultry species compared with previously reported H5N1 HPAI viruses.
[h=4]KEYWORDS:[/h] Avian influenza; H5N8; HPAI; Korea; pathogenicity; poultry
PMID: 26814367 [PubMed - as supplied by publisher]