tetano
Editor, Senior Moderator
Vet Microbiol. 2015 Sep 25. pii: S0378-1135(15)30029-8. doi: 10.1016/j.vetmic.2015.09.011. [Epub ahead of print]
[h=1]Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks (Aythya fuligula).[/h] Br?jer C[SUP]1[/SUP], van Amerongen G[SUP]2[/SUP], van de Bildt M[SUP]2[/SUP], van Run P[SUP]2[/SUP], Osterhaus A[SUP]3[/SUP], Gavier-Wid?n D[SUP]4[/SUP], Kuiken T[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Reports describing the isolation of highly pathogenic avian influenza (HPAI) virus (H5N1) clade 2.3.2 in feces from apparently healthy wild birds and the seemingly lower pathogenicity of this clade compared to clade 2.2 in several experimentally infected species, caused concern that the new clade might be maintained in the wild bird population. To investigate whether the pathogenicity of a clade 2.3.2 virus was lower than that of clades previously occurring in free-living wild birds in Europe, four tufted ducks were inoculated with influenza A/duck/HongKong/1091/2011 (H5N1) clade 2.3.2 virus. The ducks were monitored and sampled for virus excretion daily during 4 days, followed by pathologic, immunohistochemical, and virological investigations. The virus produced severe disease as evidenced by clinical signs, presence of marked lesions and abundant viral antigen in several tissues, especially the central nervous system. The study shows that HPAI-H5N1 virus clade 2.3.2 is highly pathogenic for tufted ducks and thus, they are unlikely to maintain this clade in the free-living population or serve as long-distance vectors.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Avian; Aythya fuligula; Clade 2.3.2; H5N1; HPAI; Influenza; Pathology
PMID: 26441012 [PubMed - as supplied by publisher]
[h=1]Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks (Aythya fuligula).[/h] Br?jer C[SUP]1[/SUP], van Amerongen G[SUP]2[/SUP], van de Bildt M[SUP]2[/SUP], van Run P[SUP]2[/SUP], Osterhaus A[SUP]3[/SUP], Gavier-Wid?n D[SUP]4[/SUP], Kuiken T[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Reports describing the isolation of highly pathogenic avian influenza (HPAI) virus (H5N1) clade 2.3.2 in feces from apparently healthy wild birds and the seemingly lower pathogenicity of this clade compared to clade 2.2 in several experimentally infected species, caused concern that the new clade might be maintained in the wild bird population. To investigate whether the pathogenicity of a clade 2.3.2 virus was lower than that of clades previously occurring in free-living wild birds in Europe, four tufted ducks were inoculated with influenza A/duck/HongKong/1091/2011 (H5N1) clade 2.3.2 virus. The ducks were monitored and sampled for virus excretion daily during 4 days, followed by pathologic, immunohistochemical, and virological investigations. The virus produced severe disease as evidenced by clinical signs, presence of marked lesions and abundant viral antigen in several tissues, especially the central nervous system. The study shows that HPAI-H5N1 virus clade 2.3.2 is highly pathogenic for tufted ducks and thus, they are unlikely to maintain this clade in the free-living population or serve as long-distance vectors.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Avian; Aythya fuligula; Clade 2.3.2; H5N1; HPAI; Influenza; Pathology
PMID: 26441012 [PubMed - as supplied by publisher]