tetano
Editor, Senior Moderator
J Vet Med Sci. 2017 Jul 3. doi: 10.1292/jvms.16-0619. [Epub ahead of print]
[h=1]Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets.[/h] Tsuda Y[SUP]1,[/SUP][SUP]2[/SUP], Weisend C[SUP]1[/SUP], Martellaro C[SUP]1[/SUP], Feldmann F[SUP]3[/SUP], Haddock E[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and A/Mexico/InDRE4478/2009 (H1N1) (Mex4487) derived from a mild case and from a cluster of severe cases, showed heterogeneity in virulence in a cynomolgus macaque model. To compare the more pathogenic differences, we generated recombinant viruses and compared their virulence in ferrets. Ferrets infected with recombinant Mex4487 displayed a slightly higher rate of viral replication and severe pneumonia in the early stage of infection. In contrast, prolonged lower virus shedding of recombinant Mex4108 than that of recombinant Mex4487 was detected in throat swabs. Thus, Mex4487 induces severe pneumonia in infected individuals, whereas Mex4108 might have wide-spreading potential with mild disease.
[h=4]KEYWORDS:[/h] ferret; pathogenesis; virus shedding
PMID: 28674309 DOI: 10.1292/jvms.16-0619
Free full text
[h=1]Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets.[/h] Tsuda Y[SUP]1,[/SUP][SUP]2[/SUP], Weisend C[SUP]1[/SUP], Martellaro C[SUP]1[/SUP], Feldmann F[SUP]3[/SUP], Haddock E[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and A/Mexico/InDRE4478/2009 (H1N1) (Mex4487) derived from a mild case and from a cluster of severe cases, showed heterogeneity in virulence in a cynomolgus macaque model. To compare the more pathogenic differences, we generated recombinant viruses and compared their virulence in ferrets. Ferrets infected with recombinant Mex4487 displayed a slightly higher rate of viral replication and severe pneumonia in the early stage of infection. In contrast, prolonged lower virus shedding of recombinant Mex4108 than that of recombinant Mex4487 was detected in throat swabs. Thus, Mex4487 induces severe pneumonia in infected individuals, whereas Mex4108 might have wide-spreading potential with mild disease.
[h=4]KEYWORDS:[/h] ferret; pathogenesis; virus shedding
PMID: 28674309 DOI: 10.1292/jvms.16-0619
Free full text