http://www.pnas.org/cgi/search?qbe=pnas;0607564103&journalcode=pnas&minscore=5000
pathogenecity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
tumpey, tautenberger, garcia, etc...
." The ability of the 1918 recombinant viruses to cause lethal disease in
mice without prior adaptation was remarkable given that the 1918
genes were derived directly from sequences corresponding to a
human virus. Generally, prior adaptation is required before influenza
A viruses can replicate efficiently and induce disease in mice
(35). Exceptions include some of the H5N1 viruses, which were
highly virulent in mice without prior host adaptation, isolated in
Hong Kong during 1997 (36?38) "
pathogenecity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
tumpey, tautenberger, garcia, etc...
." The ability of the 1918 recombinant viruses to cause lethal disease in
mice without prior adaptation was remarkable given that the 1918
genes were derived directly from sequences corresponding to a
human virus. Generally, prior adaptation is required before influenza
A viruses can replicate efficiently and induce disease in mice
(35). Exceptions include some of the H5N1 viruses, which were
highly virulent in mice without prior host adaptation, isolated in
Hong Kong during 1997 (36?38) "
