tetano
Editor, Senior Moderator
Pathobiology
. 2022 Mar 28;1-11.
doi: 10.1159/000522543. Online ahead of print.
Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients
Swati Srivastava[SUP] 1 [/SUP], Iti Garg[SUP] 1 [/SUP], Vikas Dogra[SUP] 2 [/SUP], Mona Bargotya[SUP] 2 [/SUP], Sonali Bhattar[SUP] 2 [/SUP], Utkarsh Gupta[SUP] 2 [/SUP], Shruti Jain[SUP] 2 [/SUP], Javid Hussain[SUP] 2 [/SUP], Anju A Hembrom[SUP] 1 [/SUP], Nilanjana Ghosh[SUP] 1 [/SUP], Vinay Kumar[SUP] 1 [/SUP], Rajeev Varshney[SUP] 1 [/SUP], Lilly Ganju[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) is a novel viral disease that spread as a global pandemic in 2020 by infecting millions of people across the world. Its clinical prognosis is dependent on various coagulatory parameters since thrombotic events are frequently associated with infection severity.
Methods: A total of 383 COVID-19 patients enrolled in Rajiv Gandhi Super Specialty Hospital, Delhi, India, were included in the present retrospective study. Patients were divided into three categories, severe (n = 141), moderate (n = 138), and mild (n = 104) based on infection severity. Various thrombotic parameters and anticoagulant levels were measured in 70 patients and further analyzed.
Results: Coagulopathy is seen in COVID-19 patients (n = 70) with a significant increase in fibrinogen, D-dimer levels, and prothrombin time in patients with severe and moderate disease compared to patients with a mild infection. Approximately, 70% of patients with severe and moderate disease demonstrated fibrinogen levels higher than the standard reference range. 60.41% of patients with severe disease showed significantly higher D-dimer levels. Thrombotic parameters were notably elevated in the nonsurvivors group compared to COVID-19 survivors. Nearly, 91% of patients with severe infection had anticoagulant protein S levels below the reference range.
Conclusion: COVID-19 infection severely impacts the blood coagulation cascade, which might lead to the manifestation of severe symptoms and increased mortality in patients.
Keywords: Coronavirus disease 2019; D-dimer; Fibrinogen; Indian population; Severe acute respiratory syndrome coronavirus 2; Thrombosis.
. 2022 Mar 28;1-11.
doi: 10.1159/000522543. Online ahead of print.
Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients
Swati Srivastava[SUP] 1 [/SUP], Iti Garg[SUP] 1 [/SUP], Vikas Dogra[SUP] 2 [/SUP], Mona Bargotya[SUP] 2 [/SUP], Sonali Bhattar[SUP] 2 [/SUP], Utkarsh Gupta[SUP] 2 [/SUP], Shruti Jain[SUP] 2 [/SUP], Javid Hussain[SUP] 2 [/SUP], Anju A Hembrom[SUP] 1 [/SUP], Nilanjana Ghosh[SUP] 1 [/SUP], Vinay Kumar[SUP] 1 [/SUP], Rajeev Varshney[SUP] 1 [/SUP], Lilly Ganju[SUP] 1 [/SUP]
Affiliations
- PMID: 35344951
- DOI: 10.1159/000522543
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) is a novel viral disease that spread as a global pandemic in 2020 by infecting millions of people across the world. Its clinical prognosis is dependent on various coagulatory parameters since thrombotic events are frequently associated with infection severity.
Methods: A total of 383 COVID-19 patients enrolled in Rajiv Gandhi Super Specialty Hospital, Delhi, India, were included in the present retrospective study. Patients were divided into three categories, severe (n = 141), moderate (n = 138), and mild (n = 104) based on infection severity. Various thrombotic parameters and anticoagulant levels were measured in 70 patients and further analyzed.
Results: Coagulopathy is seen in COVID-19 patients (n = 70) with a significant increase in fibrinogen, D-dimer levels, and prothrombin time in patients with severe and moderate disease compared to patients with a mild infection. Approximately, 70% of patients with severe and moderate disease demonstrated fibrinogen levels higher than the standard reference range. 60.41% of patients with severe disease showed significantly higher D-dimer levels. Thrombotic parameters were notably elevated in the nonsurvivors group compared to COVID-19 survivors. Nearly, 91% of patients with severe infection had anticoagulant protein S levels below the reference range.
Conclusion: COVID-19 infection severely impacts the blood coagulation cascade, which might lead to the manifestation of severe symptoms and increased mortality in patients.
Keywords: Coronavirus disease 2019; D-dimer; Fibrinogen; Indian population; Severe acute respiratory syndrome coronavirus 2; Thrombosis.