tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Dec 24. doi: 10.1111/irv.12066. [Epub ahead of print]
Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.
Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T.
Source
Department of Leukocyte Biology, Imperial College London, London, UK; Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK; Wellcome Department of Imaging Neuroscience, University College, London, UK.
Abstract
Animal models of viral respiratory disease often use weight loss as a marker of disease severity; however, this may relate to dehydration and malnutrition that would be corrected clinically. We tested whether parenteral fluid therapy improved weight loss from influenza infection. BALB/c and C57BL/6 mice were infected with A/X31 (H3N2) influenza and randomized to intraperitoneal fluid therapy. Blood glucose was also measured post-viral infection on day 3 and 6 in BALB/c mice and on day 6 in C57BL/6 mice. Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal.
? 2012 Blackwell Publishing Ltd.
PMID:
23279978
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23279978
Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.
Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T.
Source
Department of Leukocyte Biology, Imperial College London, London, UK; Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK; Wellcome Department of Imaging Neuroscience, University College, London, UK.
Abstract
Animal models of viral respiratory disease often use weight loss as a marker of disease severity; however, this may relate to dehydration and malnutrition that would be corrected clinically. We tested whether parenteral fluid therapy improved weight loss from influenza infection. BALB/c and C57BL/6 mice were infected with A/X31 (H3N2) influenza and randomized to intraperitoneal fluid therapy. Blood glucose was also measured post-viral infection on day 3 and 6 in BALB/c mice and on day 6 in C57BL/6 mice. Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal.
? 2012 Blackwell Publishing Ltd.
PMID:
23279978
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23279978