tetano
Editor, Senior Moderator
Can Assoc Radiol J. 2010 May 25. [Epub ahead of print]
Pandemic Influenza A (H1N1) 2009: Chest Radiographic Findings from 147 Proven Cases in the Montreal Area.
Semionov A, Tremblay C, Samson L, Chandonnet M, Chalaoui J, Chartrand-Lefebvre C.
Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu?bec, Canada.
Abstract
OBJECTIVE: To describe chest radiographic findings in patients with isolated and complicated acute novel influenza A (H1N1) virus infection. METHODS: Retrospective study of 147 patients (64 men, mean age 41) with reverse-transcriptase polymerase chain reaction confirmed acute influenza A (H1N1) infection, who also had a chest radiograph <72 hours of viral specimen collection. Radiographs were analysed for acute findings. A correlation with bacterial cultures results was performed. The unpaired 2-sample equal-variance Student t test was applied to continuous variables and the Pearson chi(2) test of association to discrete variables. RESULTS: In 71% of cases, chest radiograph was normal. The presence of acute imaging findings was associated with older age (P < .05), increased number of comorbidities (most commonly, chronic obstructive pulmonary disease, diabetes, asthma) (P < .05), higher rate of hospitalization (P < .05) and intensive care unit admission, and increased mortality. Predominant acute radiographic finding in isolated influenza A (H1N1) was alveolar opacity (88%), either unifocal or multifocal, most often in the lower lobes. In the subgroup of patients with positive imaging findings and for whom nonviral microbiologic data was available, 62% had superimposed bacterial or fungal infection. CONCLUSION: In the majority of patients with acute influenza A (H1N1) infection, the chest radiograph is normal. Acute imaging findings are associated with older age, an increased number of comorbidities, and a higher rate of complications and mortality. The predominant radiographic finding of isolated primary influenza A (H1N1) infection is alveolar opacity. Superimposed bacterial infection is frequent and must be excluded in patients with abnormal imaging. Copyright ? 2010 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.
PMID: 20510575 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20510575
Pandemic Influenza A (H1N1) 2009: Chest Radiographic Findings from 147 Proven Cases in the Montreal Area.
Semionov A, Tremblay C, Samson L, Chandonnet M, Chalaoui J, Chartrand-Lefebvre C.
Radiology Department, University of Montreal Medical Center (CHUM), Montreal, Qu?bec, Canada.
Abstract
OBJECTIVE: To describe chest radiographic findings in patients with isolated and complicated acute novel influenza A (H1N1) virus infection. METHODS: Retrospective study of 147 patients (64 men, mean age 41) with reverse-transcriptase polymerase chain reaction confirmed acute influenza A (H1N1) infection, who also had a chest radiograph <72 hours of viral specimen collection. Radiographs were analysed for acute findings. A correlation with bacterial cultures results was performed. The unpaired 2-sample equal-variance Student t test was applied to continuous variables and the Pearson chi(2) test of association to discrete variables. RESULTS: In 71% of cases, chest radiograph was normal. The presence of acute imaging findings was associated with older age (P < .05), increased number of comorbidities (most commonly, chronic obstructive pulmonary disease, diabetes, asthma) (P < .05), higher rate of hospitalization (P < .05) and intensive care unit admission, and increased mortality. Predominant acute radiographic finding in isolated influenza A (H1N1) was alveolar opacity (88%), either unifocal or multifocal, most often in the lower lobes. In the subgroup of patients with positive imaging findings and for whom nonviral microbiologic data was available, 62% had superimposed bacterial or fungal infection. CONCLUSION: In the majority of patients with acute influenza A (H1N1) infection, the chest radiograph is normal. Acute imaging findings are associated with older age, an increased number of comorbidities, and a higher rate of complications and mortality. The predominant radiographic finding of isolated primary influenza A (H1N1) infection is alveolar opacity. Superimposed bacterial infection is frequent and must be excluded in patients with abnormal imaging. Copyright ? 2010 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.
PMID: 20510575 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20510575