Re: "Pandemic - Bird Flu" on the Science Channel
I thought this was a very well done program. Not much new for ardent followers but a lot of well presented information. Good presentation of the situation by experts in an unvarnished manner. Good segment on personal preps.
My major concern with it was that I thought there was too much emphasis on the only one or two more mutations needed theory. There seemed to be a strong implication that we are only one or two mutations away from a pandemic virus and that these mutations involve the HA gene and receptor binding. I don't think the background science supports this ie "
The key host-specific amino acid mutations required for an avian influenza virus to function in humans are unknown" (from
http://jvi.asm.org/cgi/content/abstract/JVI.00921-07v1 Copyright (c) 2007, American Society for Microbiology
Persistent Host Markers in Pandemic and H5N1 Influenza Viruses David
B. Finkelstein, Suraj Mukatira, Perdeep K. Mehta, John C. Obenauer,
Xiaoping Su, Robert G. Webster, and Clayton W. Naeve*
Hartwell Center for Bioinformatics and Biotechnology, St. Jude
Children's Research Hospital, 332 North Lauderdale Street Memphis, TN
38105-2794, USA; Department of Infectious Diseases, St. Jude
Children's Research Hospital, 332 North Lauderdale Street Memphis, TN
38105-2794, USA; Department of Pathology, University of Tennessee
Health Science Center, Memphis, TN 38105, USA )
I think it is good to state that H5N1 is a very dangerous and persistent virus that could become a pandemic strain but I think that to imply that we are only a few mutations away and that we know what these mutations are is misleading. A lot of great work has been done but I don't think we understand completely the set of genetic traits that allow for the functional interactions between viral and host proteins that allow for efficient transmission and replication in a particular species.
(somewhat dated, it seems that current information goes to about Dec 2006 and apparently aired on BBC several months ago) But overall I thought it was excellent)
Major participants included Dr. Greg Poland, Mayo Clinic vaccine team, Gina Samaan, WHO epidemiologist in Indonesia, John Oxford, UK virologist, Dr. Jim Robertson, UK vaccine expert, Catherine Macken, Los Alamos..