tetano
Editor, Senior Moderator
Vaccine. 2010 Nov 1. [Epub ahead of print]
Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination.
Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI.
Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA.
Abstract
Understanding whether seasonal influenza vaccines can elicit antibody and T cell responses against the 2009 pandemic H1N1 strain is important. We compared T cell and antibody responses elicited by inactivated trivalent vaccine (TIV) and live attenuated influenza vaccine (LAIV) in healthy adults. Both vaccines boosted pre-existing T cells to the seasonal and pandemic hemagglutinin (HA) but responses were significantly greater following immunization with LAIV. Antibody titers were significantly boosted only by TIV. The relationship between antibody and T cell responses and the effect of the magnitude of pre-existing immunity on vaccine-induced responses were also evaluated. Cross reactive T cells to the pandemic H1N1 HA existed in some people before the circulation of the virus and were boosted by seasonal vaccination.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 21050903 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21050903
Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination.
Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI.
Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA.
Abstract
Understanding whether seasonal influenza vaccines can elicit antibody and T cell responses against the 2009 pandemic H1N1 strain is important. We compared T cell and antibody responses elicited by inactivated trivalent vaccine (TIV) and live attenuated influenza vaccine (LAIV) in healthy adults. Both vaccines boosted pre-existing T cells to the seasonal and pandemic hemagglutinin (HA) but responses were significantly greater following immunization with LAIV. Antibody titers were significantly boosted only by TIV. The relationship between antibody and T cell responses and the effect of the magnitude of pre-existing immunity on vaccine-induced responses were also evaluated. Cross reactive T cells to the pandemic H1N1 HA existed in some people before the circulation of the virus and were boosted by seasonal vaccination.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 21050903 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21050903