Re: Panasonic Says Bringing Workers Families Home Due to Pandemic Fears - Discussion, Economic Considerations, Other Companies Pan/Flu Plans
(Released 2009/2/2)
<News> January 2009, have been isolated from samples taken in hospitals in Fukuoka City, Yamagata, Sendai AH1 subtype, AH3 subtype, B antigens from the vaccine strain of influenza virus type season The divergence of
Season in Sendai, Yamagata, from clinical samples submitted from patients with flu-like hospitals in Fukuoka City as a result of MDCK antigenic analysis of influenza virus was isolated by using cells isolated AH3 subtype, AH1 subtype, B, so the trend is significantly different from the vaccine strain of virus antigen in one, and reports.
Last year (2008) to December (2009), three-four weeks until the middle of the separation of antigen-derived influenza virus in samples of urban hospitals
Antigenically to the virus isolation, National Institute of Infectious Diseases All (call infection) and ferret antisera against the vaccine strain distribution of 1.0% guinea pig blood cells using a hemagglutination inhibition (HI) test by OKONATTA.
AH1 virus subtype: HI in our value system has the ability to share vaccine antigen homolog of antibodies against infection are sharing call 1:640. The separation of viruses derived from Sendai medical institutions that most of the 61 stocks, one eighty to 160 and from 2-3 down prices Homo tube during the 1:40 and 1:20 (one share for each ), but also by the large gaps. The virus derived from the separation of medical institutions in the past 11 Hukuoka all share one eighty and HI titer was significantly misaligned. The last of these is the vaccine strain AH1 subtype A / Solomon for antiserum to stocks will not react at all (1: <10).
AH3 virus subtype: HI in our value system has the ability to share vaccine antigen homolog of antibodies against infection are sharing call 1:1280. However, the separation of Sendai in past 6 HI titer 1:640 share for four shares in the vaccine strain season A/Uruguay/716 / 2007 and are responsive to anti-serum, Inc. There has been a 1:160,1:320 is slightly misaligned and antigenicity. Meanwhile, the medical origin of Fukuoka virus, an isolate of the eight stocks are allowed to share a one eighty and a large deviation, share almost the same antigen.
B virus: HI in our value system is a homolog of the antigen test for antibody vaccine strain infection of sharing call is B/Brisbane/3/2007 Yamagata lineage viruses in reference to the antiserum and 1:2560, Victoria the virus strains B/Malaysia/2506 / 2004 for anti-serum is 1:5120.
The virus derived from the separation of medical institutions in Yamagata Prefecture in the past five shares, the shares of all the Yamagata lineage, the HI antigen titer 1:320 - 640 (each a share, share ), and 2-3 of the tube was misaligned. The Victoria-B strains are B / Malaysia for the antiserum did not react at all (1: <10).
The samples derived from hospitals in Fukuoka so far B virus are two separate stocks. Victoria shares of both the strains of the HI titer of 80, the strain B / Malaysia and was very different. The Yamagata strains are B-B / Brisbane for the antiserum did not react at all (1: <10).
Judging considered
Until now, the national AH3 subtype, AH1 subtype, B virus isolation, but as an almost 2:2:1), in Miyagi Prefecture is the separation of most AH1 virus subtype, Yamagata Initially, AH3 and B subtype was reported in the separation of the type recently AH1 is becoming mainstream and the separation of the subtype. Meanwhile, this year we have a separation from the results of medical viruses from Fukuoka week starting from, Fukuoka is currently AH3 subtype, AH1 subtype, B has been suggested that the epidemic status of cutthroat contract .
Meanwhile, as described below so that there are two points to note.
1. Prevalence of type B: In this analysis, the isolates in geographically separated areas of Fukuoka and Yamagata, Yamagata and Victoria lines and it was shown that the system is divided into. Antigenicity of both strain and "deviation" from the large, by way of the future spread of the epidemic season, so a large impact on the choice of vaccine strain in Japan next season, the virus strain surveillance become more important.
Two. Significance of monitoring for the AH1 antigenic subtype of the virus: The virus was isolated with a gene resistant to oseltamivir A/H1N1 in Japan have been major virus strain 2) a major topic in the field of the clinical has, because of this, A use of oseltamivir for pandemic flu, the site of treatment tends to be withheld. However, according to the current trend of the AH1 antigenic subtype of the virus to match the vaccine antigen, it is expected that the effectiveness of vaccination). However, our analysis was in Fukuoka in Sendai, it was suggested that necessarily. Therefore, future thinking on prevention and treatment of influenza, at the national level in addition to the survey AH1 antigenic subtype of the isolate, and research is needed about the clinical effectiveness of influenza vaccines, for drug resistance and genotypic resistance to NA inhibitors as well as activity, may have the need to quickly investigate whether the drug is clinically invalid.
Ko San
1) National Institute of Infectious Diseases Web site, flu-level maps of 2 weeks
2) IASR flu news article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html
Virus Center Clinical Research Department, National Hospital Organization Sendai Medical Center
Hiroko Nishimura Akira Tiba Humiko Itoo Hazime Hide Oumi Okamoto Mitiko
Kitaoka Setsuko Tazawa Yuusaku of Pediatrics
Miki Yuu Saito若奈of respiratory tract diseases
Nagai Nagai Yukio pediatrics, internal medicine Syouzi Makoto Shoji (Sendai more)
Shima Tsuyoshi Katsushima Humio Pediatrics (Yamagata)
Kyoko tail grass your lawn clinic, pediatric shock Shindou Shizuo, Takasaki Takasaki Yoshio Pediatrics, Pediatrics Yokohama Yamashita Yuuzi (Fukuoka or more)
http://idsc.nih.go.jp/iasr/rapid/pr3491.html
(Released 2009/2/2)
<News> January 2009, have been isolated from samples taken in hospitals in Fukuoka City, Yamagata, Sendai AH1 subtype, AH3 subtype, B antigens from the vaccine strain of influenza virus type season The divergence of
Season in Sendai, Yamagata, from clinical samples submitted from patients with flu-like hospitals in Fukuoka City as a result of MDCK antigenic analysis of influenza virus was isolated by using cells isolated AH3 subtype, AH1 subtype, B, so the trend is significantly different from the vaccine strain of virus antigen in one, and reports.
Last year (2008) to December (2009), three-four weeks until the middle of the separation of antigen-derived influenza virus in samples of urban hospitals
Antigenically to the virus isolation, National Institute of Infectious Diseases All (call infection) and ferret antisera against the vaccine strain distribution of 1.0% guinea pig blood cells using a hemagglutination inhibition (HI) test by OKONATTA.
AH1 virus subtype: HI in our value system has the ability to share vaccine antigen homolog of antibodies against infection are sharing call 1:640. The separation of viruses derived from Sendai medical institutions that most of the 61 stocks, one eighty to 160 and from 2-3 down prices Homo tube during the 1:40 and 1:20 (one share for each ), but also by the large gaps. The virus derived from the separation of medical institutions in the past 11 Hukuoka all share one eighty and HI titer was significantly misaligned. The last of these is the vaccine strain AH1 subtype A / Solomon for antiserum to stocks will not react at all (1: <10).
AH3 virus subtype: HI in our value system has the ability to share vaccine antigen homolog of antibodies against infection are sharing call 1:1280. However, the separation of Sendai in past 6 HI titer 1:640 share for four shares in the vaccine strain season A/Uruguay/716 / 2007 and are responsive to anti-serum, Inc. There has been a 1:160,1:320 is slightly misaligned and antigenicity. Meanwhile, the medical origin of Fukuoka virus, an isolate of the eight stocks are allowed to share a one eighty and a large deviation, share almost the same antigen.
B virus: HI in our value system is a homolog of the antigen test for antibody vaccine strain infection of sharing call is B/Brisbane/3/2007 Yamagata lineage viruses in reference to the antiserum and 1:2560, Victoria the virus strains B/Malaysia/2506 / 2004 for anti-serum is 1:5120.
The virus derived from the separation of medical institutions in Yamagata Prefecture in the past five shares, the shares of all the Yamagata lineage, the HI antigen titer 1:320 - 640 (each a share, share ), and 2-3 of the tube was misaligned. The Victoria-B strains are B / Malaysia for the antiserum did not react at all (1: <10).
The samples derived from hospitals in Fukuoka so far B virus are two separate stocks. Victoria shares of both the strains of the HI titer of 80, the strain B / Malaysia and was very different. The Yamagata strains are B-B / Brisbane for the antiserum did not react at all (1: <10).
Judging considered
Until now, the national AH3 subtype, AH1 subtype, B virus isolation, but as an almost 2:2:1), in Miyagi Prefecture is the separation of most AH1 virus subtype, Yamagata Initially, AH3 and B subtype was reported in the separation of the type recently AH1 is becoming mainstream and the separation of the subtype. Meanwhile, this year we have a separation from the results of medical viruses from Fukuoka week starting from, Fukuoka is currently AH3 subtype, AH1 subtype, B has been suggested that the epidemic status of cutthroat contract .
Meanwhile, as described below so that there are two points to note.
1. Prevalence of type B: In this analysis, the isolates in geographically separated areas of Fukuoka and Yamagata, Yamagata and Victoria lines and it was shown that the system is divided into. Antigenicity of both strain and "deviation" from the large, by way of the future spread of the epidemic season, so a large impact on the choice of vaccine strain in Japan next season, the virus strain surveillance become more important.
Two. Significance of monitoring for the AH1 antigenic subtype of the virus: The virus was isolated with a gene resistant to oseltamivir A/H1N1 in Japan have been major virus strain 2) a major topic in the field of the clinical has, because of this, A use of oseltamivir for pandemic flu, the site of treatment tends to be withheld. However, according to the current trend of the AH1 antigenic subtype of the virus to match the vaccine antigen, it is expected that the effectiveness of vaccination). However, our analysis was in Fukuoka in Sendai, it was suggested that necessarily. Therefore, future thinking on prevention and treatment of influenza, at the national level in addition to the survey AH1 antigenic subtype of the isolate, and research is needed about the clinical effectiveness of influenza vaccines, for drug resistance and genotypic resistance to NA inhibitors as well as activity, may have the need to quickly investigate whether the drug is clinically invalid.
Ko San
1) National Institute of Infectious Diseases Web site, flu-level maps of 2 weeks
2) IASR flu news article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html
Virus Center Clinical Research Department, National Hospital Organization Sendai Medical Center
Hiroko Nishimura Akira Tiba Humiko Itoo Hazime Hide Oumi Okamoto Mitiko
Kitaoka Setsuko Tazawa Yuusaku of Pediatrics
Miki Yuu Saito若奈of respiratory tract diseases
Nagai Nagai Yukio pediatrics, internal medicine Syouzi Makoto Shoji (Sendai more)
Shima Tsuyoshi Katsushima Humio Pediatrics (Yamagata)
Kyoko tail grass your lawn clinic, pediatric shock Shindou Shizuo, Takasaki Takasaki Yoshio Pediatrics, Pediatrics Yokohama Yamashita Yuuzi (Fukuoka or more)
http://idsc.nih.go.jp/iasr/rapid/pr3491.html
