Mary Wilson
New member
August 18, 2021
DOI: 10.1056/NEJMoa2108453
Chee-Wah Tan, Ph.D., Wan-Ni Chia, Ph.D., Barnaby E. Young, M.R.C.P., Feng Zhu, Ph.D., Beng-Lee Lim, M.Sc., Wan-Rong Sia, B.S., Tun-Linn Thein, M.P.H., Mark I.-C. Chen, Ph.D., Yee-Sin Leo, F.R.C.P.,
David C. Lye, F.R.C.P., and Lin-Fa Wang, Ph.D.
Summary
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal. Here we provide data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies are induced in survivors of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) infection who have been immunized with the BNT162b2 messenger RNA (mRNA) vaccine. The antibodies are high-level and broad-spectrum, capable of neutralizing not only known variants of concern but also sarbecoviruses that have been identified in bats and pangolins and that have the potential to cause human infection. These findings show the feasibility of a pan-sarbecovirus vaccine strategy.
https://www.nejm.org/doi/full/10.1056/NEJMoa2108453?query=featured_home
DOI: 10.1056/NEJMoa2108453
Chee-Wah Tan, Ph.D., Wan-Ni Chia, Ph.D., Barnaby E. Young, M.R.C.P., Feng Zhu, Ph.D., Beng-Lee Lim, M.Sc., Wan-Rong Sia, B.S., Tun-Linn Thein, M.P.H., Mark I.-C. Chen, Ph.D., Yee-Sin Leo, F.R.C.P.,
David C. Lye, F.R.C.P., and Lin-Fa Wang, Ph.D.
Summary
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal. Here we provide data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies are induced in survivors of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) infection who have been immunized with the BNT162b2 messenger RNA (mRNA) vaccine. The antibodies are high-level and broad-spectrum, capable of neutralizing not only known variants of concern but also sarbecoviruses that have been identified in bats and pangolins and that have the potential to cause human infection. These findings show the feasibility of a pan-sarbecovirus vaccine strategy.
https://www.nejm.org/doi/full/10.1056/NEJMoa2108453?query=featured_home