tetano
Editor, Senior Moderator
J Virol. 2012 Feb 15. [Epub ahead of print]
Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.
Seibert CW, Rahmat S, Krammer F, Palese P, Bouvier NM.
Source
Department of Microbiology.
Abstract
The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.
PMID:
22345446
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22345446
Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.
Seibert CW, Rahmat S, Krammer F, Palese P, Bouvier NM.
Source
Department of Microbiology.
Abstract
The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.
PMID:
22345446
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22345446