Commonground
Senior Moderator
1 June 2026
The Coalition for Epidemic Preparedness Innovations (CEPI) has announced today that it will urgently accelerate the development of three investigational vaccines targeting the Bundibugyo ebolavirus that has caused a rapidly spreading epidemic in the Democratic Republic of the Congo (DRC) and neighbouring Uganda, including one being developed by the Oxford Vaccine Group at the University of Oxford.
The funding will advance each vaccine candidate, so they are ready to begin clinical trials as quickly as possible. The University of Oxford vaccine will be manufactured at the Serum Institute of India.
With no licensed vaccines available or in clinical trials for Bundibugyo virus, this action reflects the critical need to produce tools to help curtail the outbreak, complementing ongoing public health interventions by affected countries.
‘With Bundibugyo virus spreading rapidly and no licensed vaccines, every day counts in the race against this deadly disease,’ said Dr Richard Hatchett, CEO of CEPI. "CEPI’s urgent funding and support for these three promising candidates aims to advance safe, effective vaccines to help control this epidemic."
H.E. Dr Jean Kaseya, Director General of Africa CDC welcomes CEPI's swift action and that of the vaccine research teams and developers.“As we respond to an active Ebola outbreak in Africa, CEPI’s investment in three Bundibugyo ebolavirus vaccine candidates is both timely and critical to Africa’s health - as well as economic security and advancing Africa’s ambition to build sustainable R&D and vaccine manufacturing capacity on the continent."
The current outbreak - declared a Public Health Emergency of International Concern (PHEIC) and a Public Health Emergency of Continental Security (PHECS) by the World Health Organisation and Africa CDC, respectively - has already caused more than 900 suspected cases and more than 220 suspected deaths, making it the third largest Filovirus outbreak in history.
Professor Teresa Lambe OBE, Calleva Head of Vaccine Immunology, Oxford Vaccine group and the Pandemic Sciences Institute, Nuffield Department of Medicine said: "We are grateful to work with CEPI and our global partners, including SII, to advance our candidate vaccine against BDBV. We are hopeful that through a coordinated global effort, we will be able to curb this outbreak and stop this virus in its tracks."
The three vaccine candidates were selected based on CEPI's comprehensive global review of Bundibugyo virus vaccines in development and extensive consultation with WHO, Africa CDC, ANRS-MIE, Gavi and affected countries. Each uses a different validated vaccine technology to maximise the likelihood of success.
Adar Poonawalla, CEO of the Serum Institute of India, said: "At moments like this, speed, scale and access is all that matters. SII will bring its manufacturing capabilities to this collaboration with CEPI and the University of Oxford to help advance a Bundibugyo virus vaccine candidate as quickly as possible, while supporting the shared goal of affordable access for affected countries if the vaccine proves successful."
All of the underlying vaccine technology platforms have extensive safety data and have been used to develop vaccine candidates that have shown preclinical or clinical efficacy against related filoviruses. CEPI has committed initial funding of up to US$8.6 million to fund preclinical testing and other development activities to rapidly prepare for Phase 1 trials of a vaccine based on the University of Oxford's ChAdOx1 platform, which underpinned the Oxford/AstraZeneca COVID-19 vaccine. The funding will also support creation of a Master Virus Seed stock and manufacturing of clinical-grade doses at SII under CEPI’s pre-existing agreement with the company. This programme leverages CEPI's existing strategic partnership with the University of Oxford and SII's participation in CEPI's Vaccine Manufacturing Facility Network.
The epidemic, alongside recent Hantavirus outbreaks, underscores the urgent need to strengthen public health responses, accelerate medical countermeasures development, and invest in preparedness for increasingly complex infectious disease threats. CEPI's response reinforces the importance of advancing R&D across viral families, strengthening vaccine platform readiness, and maintaining ready-to-activate networks - capabilities essential to delivering the 100 Days Mission and enabling equitable, rapid and resilient epidemic and pandemic responses.
https://www.psi.ox.ac.uk/news-and-o...virus-vaccine-candidate-receives-cepi-backing
The Coalition for Epidemic Preparedness Innovations (CEPI) has announced today that it will urgently accelerate the development of three investigational vaccines targeting the Bundibugyo ebolavirus that has caused a rapidly spreading epidemic in the Democratic Republic of the Congo (DRC) and neighbouring Uganda, including one being developed by the Oxford Vaccine Group at the University of Oxford.
The funding will advance each vaccine candidate, so they are ready to begin clinical trials as quickly as possible. The University of Oxford vaccine will be manufactured at the Serum Institute of India.
With no licensed vaccines available or in clinical trials for Bundibugyo virus, this action reflects the critical need to produce tools to help curtail the outbreak, complementing ongoing public health interventions by affected countries.
‘With Bundibugyo virus spreading rapidly and no licensed vaccines, every day counts in the race against this deadly disease,’ said Dr Richard Hatchett, CEO of CEPI. "CEPI’s urgent funding and support for these three promising candidates aims to advance safe, effective vaccines to help control this epidemic."
H.E. Dr Jean Kaseya, Director General of Africa CDC welcomes CEPI's swift action and that of the vaccine research teams and developers.“As we respond to an active Ebola outbreak in Africa, CEPI’s investment in three Bundibugyo ebolavirus vaccine candidates is both timely and critical to Africa’s health - as well as economic security and advancing Africa’s ambition to build sustainable R&D and vaccine manufacturing capacity on the continent."
The current outbreak - declared a Public Health Emergency of International Concern (PHEIC) and a Public Health Emergency of Continental Security (PHECS) by the World Health Organisation and Africa CDC, respectively - has already caused more than 900 suspected cases and more than 220 suspected deaths, making it the third largest Filovirus outbreak in history.
Professor Teresa Lambe OBE, Calleva Head of Vaccine Immunology, Oxford Vaccine group and the Pandemic Sciences Institute, Nuffield Department of Medicine said: "We are grateful to work with CEPI and our global partners, including SII, to advance our candidate vaccine against BDBV. We are hopeful that through a coordinated global effort, we will be able to curb this outbreak and stop this virus in its tracks."
The three vaccine candidates were selected based on CEPI's comprehensive global review of Bundibugyo virus vaccines in development and extensive consultation with WHO, Africa CDC, ANRS-MIE, Gavi and affected countries. Each uses a different validated vaccine technology to maximise the likelihood of success.
Adar Poonawalla, CEO of the Serum Institute of India, said: "At moments like this, speed, scale and access is all that matters. SII will bring its manufacturing capabilities to this collaboration with CEPI and the University of Oxford to help advance a Bundibugyo virus vaccine candidate as quickly as possible, while supporting the shared goal of affordable access for affected countries if the vaccine proves successful."
All of the underlying vaccine technology platforms have extensive safety data and have been used to develop vaccine candidates that have shown preclinical or clinical efficacy against related filoviruses. CEPI has committed initial funding of up to US$8.6 million to fund preclinical testing and other development activities to rapidly prepare for Phase 1 trials of a vaccine based on the University of Oxford's ChAdOx1 platform, which underpinned the Oxford/AstraZeneca COVID-19 vaccine. The funding will also support creation of a Master Virus Seed stock and manufacturing of clinical-grade doses at SII under CEPI’s pre-existing agreement with the company. This programme leverages CEPI's existing strategic partnership with the University of Oxford and SII's participation in CEPI's Vaccine Manufacturing Facility Network.
The epidemic, alongside recent Hantavirus outbreaks, underscores the urgent need to strengthen public health responses, accelerate medical countermeasures development, and invest in preparedness for increasingly complex infectious disease threats. CEPI's response reinforces the importance of advancing R&D across viral families, strengthening vaccine platform readiness, and maintaining ready-to-activate networks - capabilities essential to delivering the 100 Days Mission and enabling equitable, rapid and resilient epidemic and pandemic responses.
https://www.psi.ox.ac.uk/news-and-o...virus-vaccine-candidate-receives-cepi-backing
