tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2014 Sep 22;1(2)
fu086. doi: 10.1093/ofid/ofu086. eCollection 2014.
[h=1]Other respiratory viruses are important contributors to adult respiratory hospitalizations and mortality even during peak weeks of the influenza season.[/h] Gilca R[SUP]1[/SUP], Amini R[SUP]2[/SUP], Douville-Fradet M[SUP]2[/SUP], Charest H[SUP]3[/SUP], Dubuque J[SUP]4[/SUP], Boulianne N[SUP]5[/SUP], Skowronski DM[SUP]6[/SUP], De Serres G[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] During peak weeks of seasonal influenza epidemics, severe respiratory infections without laboratory confirmation are typically attributed to influenza.
[h=4]METHODS:[/h] In this prospective study, specimens and demographic and clinical data were collected from adults admitted with respiratory symptoms to 4 hospitals during the 8-10 peak weeks of 2 influenza seasons. Specimens were systematically tested for influenza and 13 other respiratory viruses (ORVs) by using the Luminex RVP FAST assay.
[h=4]RESULTS:[/h] At least 1 respiratory virus was identified in 46% (21% influenza, 25% noninfluenza; 2% coinfection) of the 286 enrolled patients in 2011-2012 and in 62% (46% influenza, 16% noninfluenza; 3% coinfection) of the 396 enrolled patients in 2012-2013. Among patients aged ≥75 years, twice as many ORVs (32%) as influenza viruses (14%) were detected in 2011-2012. During both seasons, the most frequently detected ORVs were enteroviruses/rhinoviruses (7%), respiratory syncytial virus (6%), human metapneumovirus (5%), coronaviruses (4%), and parainfluenza viruses (2%). Disease severity was similar for influenza and ORVs during both seasons.
[h=4]CONCLUSIONS:[/h] Although ORV contribution relative to influenza varies by age and season, during the peak weeks of certain influenza seasons, ORVs may be a more frequent cause of elderly hospitalization than influenza.
[h=4]KEYWORDS:[/h] adults; elderly; hospitalization; influenza; mortality; respiratory viruses
PMID: 25734152 [PubMed] PMCID: PMC4281811 Free PMC Article
fu086. doi: 10.1093/ofid/ofu086. eCollection 2014.[h=1]Other respiratory viruses are important contributors to adult respiratory hospitalizations and mortality even during peak weeks of the influenza season.[/h] Gilca R[SUP]1[/SUP], Amini R[SUP]2[/SUP], Douville-Fradet M[SUP]2[/SUP], Charest H[SUP]3[/SUP], Dubuque J[SUP]4[/SUP], Boulianne N[SUP]5[/SUP], Skowronski DM[SUP]6[/SUP], De Serres G[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] During peak weeks of seasonal influenza epidemics, severe respiratory infections without laboratory confirmation are typically attributed to influenza.
[h=4]METHODS:[/h] In this prospective study, specimens and demographic and clinical data were collected from adults admitted with respiratory symptoms to 4 hospitals during the 8-10 peak weeks of 2 influenza seasons. Specimens were systematically tested for influenza and 13 other respiratory viruses (ORVs) by using the Luminex RVP FAST assay.
[h=4]RESULTS:[/h] At least 1 respiratory virus was identified in 46% (21% influenza, 25% noninfluenza; 2% coinfection) of the 286 enrolled patients in 2011-2012 and in 62% (46% influenza, 16% noninfluenza; 3% coinfection) of the 396 enrolled patients in 2012-2013. Among patients aged ≥75 years, twice as many ORVs (32%) as influenza viruses (14%) were detected in 2011-2012. During both seasons, the most frequently detected ORVs were enteroviruses/rhinoviruses (7%), respiratory syncytial virus (6%), human metapneumovirus (5%), coronaviruses (4%), and parainfluenza viruses (2%). Disease severity was similar for influenza and ORVs during both seasons.
[h=4]CONCLUSIONS:[/h] Although ORV contribution relative to influenza varies by age and season, during the peak weeks of certain influenza seasons, ORVs may be a more frequent cause of elderly hospitalization than influenza.
[h=4]KEYWORDS:[/h] adults; elderly; hospitalization; influenza; mortality; respiratory viruses
PMID: 25734152 [PubMed] PMCID: PMC4281811 Free PMC Article