tetano
Editor, Senior Moderator
Int J Antimicrob Agents. 2012 May 14. [Epub ahead of print]
Oseltamivir-resistant influenza A(H1N1) 2009 virus in Greece during the post-pandemic 2010-2011 season.
Kourti A, Spanakos G, Politi L, Stavropoulou A, Spanakis N, Tsakris A.
Source
Virology Unit, Department of Microbiology, Medical School, University of Athens, 11527 Athens, Greece.
Abstract
Information on the drug susceptibility of influenza epidemic strains is important for antiviral resistance monitoring. In Greece, the 2009-2010 pandemic waves were very mild and seroprevalence rates remained low after this influenza season, resulting in exclusive detection of the pandemic strain during the 2010-2011 influenza season. In the present study during the post-pandemic 2010-2011 season, 50 consecutive influenza A(H1N1) 2009 virus-positive samples from patients hospitalised in Greek hospitals were analysed for resistance to the neuraminidase inhibitor oseltamivir. All patients were hospitalised with severe influenza complications and had previously received oseltamivir. Influenza A(H1N1) 2009 virus detection and testing for oseltamivir resistance were performed with real-time PCR amplification assays. The H275Y substitution associated with resistance to oseltamivir was identified in two immunocompetent patients who received oseltamivir treatment for 3 days and 5 days, respectively. In both cases, patients were discharged in good condition despite development of resistance to antiviral treatment.
Copyright ? 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
PMID:
22591839
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22591839
Oseltamivir-resistant influenza A(H1N1) 2009 virus in Greece during the post-pandemic 2010-2011 season.
Kourti A, Spanakos G, Politi L, Stavropoulou A, Spanakis N, Tsakris A.
Source
Virology Unit, Department of Microbiology, Medical School, University of Athens, 11527 Athens, Greece.
Abstract
Information on the drug susceptibility of influenza epidemic strains is important for antiviral resistance monitoring. In Greece, the 2009-2010 pandemic waves were very mild and seroprevalence rates remained low after this influenza season, resulting in exclusive detection of the pandemic strain during the 2010-2011 influenza season. In the present study during the post-pandemic 2010-2011 season, 50 consecutive influenza A(H1N1) 2009 virus-positive samples from patients hospitalised in Greek hospitals were analysed for resistance to the neuraminidase inhibitor oseltamivir. All patients were hospitalised with severe influenza complications and had previously received oseltamivir. Influenza A(H1N1) 2009 virus detection and testing for oseltamivir resistance were performed with real-time PCR amplification assays. The H275Y substitution associated with resistance to oseltamivir was identified in two immunocompetent patients who received oseltamivir treatment for 3 days and 5 days, respectively. In both cases, patients were discharged in good condition despite development of resistance to antiviral treatment.
Copyright ? 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
PMID:
22591839
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22591839