Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort s

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n Infect Dis. 2019 Sep 20. pii: ciz904. doi: 10.1093/cid/ciz904. [Epub ahead of print] [h=1]Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort study.[/h] Behillil S[SUP]1[/SUP], May F[SUP]2,[/SUP][SUP]3[/SUP], Fourati S[SUP]4[/SUP], Luyt CE[SUP]5[/SUP], Chicheportiche T[SUP]5[/SUP], Sonneville R[SUP]6[/SUP], Tandjaoui-Lambiotte Y[SUP]7[/SUP], Roux D[SUP]8[/SUP], Gu?rin L[SUP]9[/SUP], Mayaux J[SUP]10[/SUP], Maury E[SUP]11[/SUP], Ferr? A[SUP]12[/SUP], Georger JF[SUP]13[/SUP], Voiriot G[SUP]14[/SUP], Enouf V[SUP]1[/SUP], van der Werf S[SUP]1[/SUP], Dessap AM[SUP]2,[/SUP][SUP]3[/SUP], de Prost N[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day-28 mortality than others (80% vs 12%; p=0.011).
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


[h=4]KEYWORDS:[/h] Influenza A Virus, H1N1 Subtype; Oseltamivir; Pneumonia, Viral; Respiratory Distress Syndrome, Adult

PMID: 31538643 DOI: 10.1093/cid/ciz904