tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2011 Dec 12. [Epub ahead of print]
Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.
Belser JA, Sleeman K, Pearce MB, Katz JM, Gubareva LV, Tumpey TM.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.
Abstract
The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors, and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.
PMID:
22155827
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22155827
Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.
Belser JA, Sleeman K, Pearce MB, Katz JM, Gubareva LV, Tumpey TM.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.
Abstract
The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors, and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.
PMID:
22155827
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22155827