tetano
Editor, Senior Moderator
The Journal of Infectious Diseases 2010;202:563?566
? 2010 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2010/20204-0008$15.00
DOI: 10.1086/654930
BRIEF REPORT
Oseltamivir Dosing for Influenza Infection in Premature Neonates
Edward P. Acosta,1,2
Penelope Jester,2
Peter Gal,3
John Wimmer,3
Joni Wade,3
Richard J. Whitley,2 and
David W. Kimberlin2;
for the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
1Division of Clinical Pharmacology and 2Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham; and 3Women?s Hospital of Greensboro, Greensboro, North Carolina
Under the Emergency Use Authorization issued in April 2009, oseltamivir can be used to treat 2009 influenza A (H1N1) virus infection in children aged <1 year. No data exist on the dosing of oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 influenza A (H1N1); a protocol was expeditiously implemented to collect samples for pharmacokinetics and dosage evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to that in older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population.
http://www.journals.uchicago.edu/doi/abs/10.1086/654930
? 2010 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2010/20204-0008$15.00
DOI: 10.1086/654930
BRIEF REPORT
Oseltamivir Dosing for Influenza Infection in Premature Neonates
Edward P. Acosta,1,2
Penelope Jester,2
Peter Gal,3
John Wimmer,3
Joni Wade,3
Richard J. Whitley,2 and
David W. Kimberlin2;
for the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
1Division of Clinical Pharmacology and 2Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham; and 3Women?s Hospital of Greensboro, Greensboro, North Carolina
Under the Emergency Use Authorization issued in April 2009, oseltamivir can be used to treat 2009 influenza A (H1N1) virus infection in children aged <1 year. No data exist on the dosing of oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 influenza A (H1N1); a protocol was expeditiously implemented to collect samples for pharmacokinetics and dosage evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to that in older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population.
http://www.journals.uchicago.edu/doi/abs/10.1086/654930