tetano
Editor, Senior Moderator
J Infect Dis. 2010 Jul 1. [Epub ahead of print]
Oseltamivir Dosing for Influenza Infection in Premature Neonates.
Acosta EP, Jester P, Gal P, Wimmer J, Wade J, Whitley RJ, Kimberlin DW.
Division of Clinical Pharmacology and 2Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham; and 3Women's Hospital of Greensboro, Greensboro, North Carolina.
Abstract
Under the Emergency Use Authorization issued in April 2009, oseltamivir can be used to treat 2009 influenza A (H1N1) virus infection in children aged <1 year. No data exist on the dosing of oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 influenza A (H1N1); a protocol was expeditiously implemented to collect samples for pharmacokinetics and dosage evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to that in older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population.
PMID: 20594104 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20594104
Oseltamivir Dosing for Influenza Infection in Premature Neonates.
Acosta EP, Jester P, Gal P, Wimmer J, Wade J, Whitley RJ, Kimberlin DW.
Division of Clinical Pharmacology and 2Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham; and 3Women's Hospital of Greensboro, Greensboro, North Carolina.
Abstract
Under the Emergency Use Authorization issued in April 2009, oseltamivir can be used to treat 2009 influenza A (H1N1) virus infection in children aged <1 year. No data exist on the dosing of oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 influenza A (H1N1); a protocol was expeditiously implemented to collect samples for pharmacokinetics and dosage evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to that in older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population.
PMID: 20594104 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20594104