tetano
Editor, Senior Moderator
Oxford Journals
Medicine
Clinical Infectious Diseases
Advance Access
10.1093/cid/cir400
Oseltamivir and Risk of Lower Respiratory Tract Complications in Patients With Flu Symptoms: A Meta-analysis of Eleven Randomized Clinical Trials
Miguel A. Hern?n1,2 and
Marc Lipsitch1,3
+ Author Affiliations
1Department of Epidemiology, Harvard School of Public Health
2Harvard-MIT Division of Health Sciences and Technology
3Center for Communicable Disease Dynamics and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
Correspondence: Miguel Hern?n, MD, DrPH, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 (miguel_hernan@post.harvard.edu).
Abstract
An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%?42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%?52%).
Received November 12, 2010.
Accepted May 17, 2011
http://cid.oxfordjournals.org/content/early/2011/06/14/cid.cir400.short?rss=1
Medicine
Clinical Infectious Diseases
Advance Access
10.1093/cid/cir400
Oseltamivir and Risk of Lower Respiratory Tract Complications in Patients With Flu Symptoms: A Meta-analysis of Eleven Randomized Clinical Trials
Miguel A. Hern?n1,2 and
Marc Lipsitch1,3
+ Author Affiliations
1Department of Epidemiology, Harvard School of Public Health
2Harvard-MIT Division of Health Sciences and Technology
3Center for Communicable Disease Dynamics and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
Correspondence: Miguel Hern?n, MD, DrPH, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 (miguel_hernan@post.harvard.edu).
Abstract
An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%?42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%?52%).
Received November 12, 2010.
Accepted May 17, 2011
http://cid.oxfordjournals.org/content/early/2011/06/14/cid.cir400.short?rss=1