tetano
Editor, Senior Moderator
Orphanet J Rare Dis
. 2025 Aug 3;20(1):396.
doi: 10.1186/s13023-025-03944-5. Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China
Zhenglong Guo[SUP] 1 2 [/SUP], Ruili Wang[SUP] 1 2 [/SUP], Wenke Yang[SUP] 1 2 [/SUP], Xin Chen[SUP] 1 2 [/SUP], Bingtao Hao[SUP] 3 4 [/SUP], Shixiu Liao[SUP] 5 6 [/SUP]
Affiliations
Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus.
Keywords: Pregnancy outcomes; SARS-CoV2; Situs inversus.
. 2025 Aug 3;20(1):396.
doi: 10.1186/s13023-025-03944-5. Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China
Zhenglong Guo[SUP] 1 2 [/SUP], Ruili Wang[SUP] 1 2 [/SUP], Wenke Yang[SUP] 1 2 [/SUP], Xin Chen[SUP] 1 2 [/SUP], Bingtao Hao[SUP] 3 4 [/SUP], Shixiu Liao[SUP] 5 6 [/SUP]
Affiliations
- PMID: 40754591
- DOI: 10.1186/s13023-025-03944-5
Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus.
Keywords: Pregnancy outcomes; SARS-CoV2; Situs inversus.