tetano
Editor, Senior Moderator
Oral Sci Int
. 2020 Sep 28;10.1002/osi2.1085.
doi: 10.1002/osi2.1085. Online ahead of print.
Brief communication: Immunohistochemical detection of ACE2 in human salivary gland
Yu Usami[SUP] 1 [/SUP], Katsutoshi Hirose[SUP] 1 [/SUP], Masashi Okumura[SUP] 1 2 [/SUP], Satoru Toyosawa[SUP] 1 [/SUP], Takayoshi Sakai[SUP] 3 [/SUP]
Affiliations
Abstract
The novel, severe acute respiratory syndrome coronavirus (SARS-CoV-2) was firstly reported in late December of 2019 and subsequently caused a global outbreak. It has been shown that SARS-CoV-2 uses ACE2 (Angiotensin Converting Enzyme 2) as a cellular receptor for host cell entry through the surface unit of SARS-CoV spike glycoprotein. In this brief report, we analyze ACE2 protein expression and localization in human salivary gland, and propose a possible role of saliva in the pathogenesis of Coronavirus disease 2019 (COVID-19).
Keywords: COVID‐19; SARS‐CoV‐2; aspiration pneumonia; salivary gland.
. 2020 Sep 28;10.1002/osi2.1085.
doi: 10.1002/osi2.1085. Online ahead of print.
Brief communication: Immunohistochemical detection of ACE2 in human salivary gland
Yu Usami[SUP] 1 [/SUP], Katsutoshi Hirose[SUP] 1 [/SUP], Masashi Okumura[SUP] 1 2 [/SUP], Satoru Toyosawa[SUP] 1 [/SUP], Takayoshi Sakai[SUP] 3 [/SUP]
Affiliations
- PMID: 33041626
- PMCID: PMC7537151
- DOI: 10.1002/osi2.1085
Abstract
The novel, severe acute respiratory syndrome coronavirus (SARS-CoV-2) was firstly reported in late December of 2019 and subsequently caused a global outbreak. It has been shown that SARS-CoV-2 uses ACE2 (Angiotensin Converting Enzyme 2) as a cellular receptor for host cell entry through the surface unit of SARS-CoV spike glycoprotein. In this brief report, we analyze ACE2 protein expression and localization in human salivary gland, and propose a possible role of saliva in the pathogenesis of Coronavirus disease 2019 (COVID-19).
Keywords: COVID‐19; SARS‐CoV‐2; aspiration pneumonia; salivary gland.