tetano
Editor, Senior Moderator
Ophthalmol
. 2022 Mar 29;2022:4643973.
doi: 10.1155/2022/4643973. eCollection 2022.
Peripapillary Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Patients Recovered from COVID-19: A Longitudinal Study
Mojtaba Abrishami[SUP] 1 [/SUP], Kiana Hassanpour[SUP] 2 [/SUP], SeyedehMaryam Hosseini[SUP] 1 [/SUP], Nasser Shoeibi[SUP] 1 [/SUP], Mohammad Reza Ansari-Astaneh[SUP] 1 [/SUP], Zahra Emamverdian[SUP] 1 [/SUP], Bahareh Gharib[SUP] 1 [/SUP], Nasibeh Amini[SUP] 1 [/SUP], Majid Abrishami[SUP] 1 [/SUP]
Affiliations
Abstract
Purpose: To quantify the longitudinal changes of the optic nerve head (ONH) parameters and peripapillary retinal nerve fiber layer (pRNFL) thickness in patients recovered from coronavirus disease 2019 (COVID-19) using spectral-domain optical coherence tomography (OCT) analysis.
Materials and methods: In an observational longitudinal study, in patients recovered from COVID-19, ONH OCT images were recorded at least two weeks after recovery from the systemic disease as the baseline and after one and three-month follow-up. Ganglion cell complex (GCC) analysis, ONH parameters, and pRNFL thickness changes were measured.
Results: A total of 36 eyes from 18 recovered COVID-19 patients including eleven (61.2%) females were studied. The average age was 35.5 ± 7.5 years. The pRNFL thickness in the nasal lower sector significantly decreased from 77 ± 18 μm in the first post-COVID-19 month to 74 ± 10 μm in the third month (P=0.8). The average, superior, and inferior pRNFL thickness remained unchanged. The average cup volume significantly decreased from 0.27 ± 0.15 mm[SUP]3[/SUP] at baseline to 0.19 ± 0.15 mm[SUP]3[/SUP] in the third post-COVID-19 visit (P=0.028). In terms of ONH morphologies including rim, disc and cup to disc area, and the vertical and horizontal ratio, the changes were not significant over the 3-month study period. Focal loss volume and global loss volume values were not changed significantly.
Conclusion: Localized defect in the nasal lower sector of pRNFL is observed in 3-month post-recovery from COVID-19. Larger studies with longer follow-ups are required to reveal the exact changes in ONH parameters.
. 2022 Mar 29;2022:4643973.
doi: 10.1155/2022/4643973. eCollection 2022.
Peripapillary Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Patients Recovered from COVID-19: A Longitudinal Study
Mojtaba Abrishami[SUP] 1 [/SUP], Kiana Hassanpour[SUP] 2 [/SUP], SeyedehMaryam Hosseini[SUP] 1 [/SUP], Nasser Shoeibi[SUP] 1 [/SUP], Mohammad Reza Ansari-Astaneh[SUP] 1 [/SUP], Zahra Emamverdian[SUP] 1 [/SUP], Bahareh Gharib[SUP] 1 [/SUP], Nasibeh Amini[SUP] 1 [/SUP], Majid Abrishami[SUP] 1 [/SUP]
Affiliations
- PMID: 35368999
- PMCID: PMC8968351
- DOI: 10.1155/2022/4643973
Abstract
Purpose: To quantify the longitudinal changes of the optic nerve head (ONH) parameters and peripapillary retinal nerve fiber layer (pRNFL) thickness in patients recovered from coronavirus disease 2019 (COVID-19) using spectral-domain optical coherence tomography (OCT) analysis.
Materials and methods: In an observational longitudinal study, in patients recovered from COVID-19, ONH OCT images were recorded at least two weeks after recovery from the systemic disease as the baseline and after one and three-month follow-up. Ganglion cell complex (GCC) analysis, ONH parameters, and pRNFL thickness changes were measured.
Results: A total of 36 eyes from 18 recovered COVID-19 patients including eleven (61.2%) females were studied. The average age was 35.5 ± 7.5 years. The pRNFL thickness in the nasal lower sector significantly decreased from 77 ± 18 μm in the first post-COVID-19 month to 74 ± 10 μm in the third month (P=0.8). The average, superior, and inferior pRNFL thickness remained unchanged. The average cup volume significantly decreased from 0.27 ± 0.15 mm[SUP]3[/SUP] at baseline to 0.19 ± 0.15 mm[SUP]3[/SUP] in the third post-COVID-19 visit (P=0.028). In terms of ONH morphologies including rim, disc and cup to disc area, and the vertical and horizontal ratio, the changes were not significant over the 3-month study period. Focal loss volume and global loss volume values were not changed significantly.
Conclusion: Localized defect in the nasal lower sector of pRNFL is observed in 3-month post-recovery from COVID-19. Larger studies with longer follow-ups are required to reveal the exact changes in ONH parameters.