tetano
Editor, Senior Moderator
Open Life Sci
. 2021 Jun 2;16(1):558-570.
doi: 10.1515/biol-2021-0051. eCollection 2021.
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
Fouad A Abolaban[SUP] 1 [/SUP], Fathi M Djouider[SUP] 1 [/SUP]
Affiliations
Abstract
Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.
Keywords: SARS-CoV-2 virus; gamma irradiation; vaccine development; virus genome; virus inactivation; virus infectivity.
. 2021 Jun 2;16(1):558-570.
doi: 10.1515/biol-2021-0051. eCollection 2021.
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
Fouad A Abolaban[SUP] 1 [/SUP], Fathi M Djouider[SUP] 1 [/SUP]
Affiliations
- PMID: 34131589
- PMCID: PMC8174122
- DOI: 10.1515/biol-2021-0051
Abstract
Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.
Keywords: SARS-CoV-2 virus; gamma irradiation; vaccine development; virus genome; virus inactivation; virus infectivity.