tetano
Editor, Senior Moderator
Open Heart
. 2024 May 27;11(1):e002662.
doi: 10.1136/openhrt-2024-002662. Long COVID and cardiovascular disease: a prospective cohort study
Claire Alexandra Lawson[SUP] 1 [/SUP], Alastair James Moss[SUP] 1 [/SUP], Jayanth Ranjit Arnold[SUP] 1 [/SUP], Catherine Bagot[SUP] 2 [/SUP], Amitava Banerjee[SUP] 3 [/SUP], Colin Berry[SUP] 4 5 [/SUP], John Greenwood[SUP] 6 7 [/SUP], Alun D Hughes[SUP] 8 [/SUP], Kamlesh Khunti[SUP] 9 [/SUP], Nicholas L Mills[SUP] 10 [/SUP], Stefan Neubauer[SUP] 11 [/SUP], Betty Raman[SUP] 11 [/SUP], Naveed Sattar[SUP] 12 [/SUP], Olivia C Leavy[SUP] 13 [/SUP], Matthew Richardson[SUP] 14 [/SUP], Omer Elneima[SUP] 14 [/SUP], Hamish Jc McAuley[SUP] 14 [/SUP], Aarti Shikotra[SUP] 14 [/SUP], Amisha Singapuri[SUP] 14 [/SUP], Marco Sereno[SUP] 14 [/SUP], Ruth Saunders[SUP] 14 [/SUP], Victoria Harris[SUP] 14 [/SUP], Linzy Houchen-Wolloff[SUP] 14 [/SUP], Neil J Greening[SUP] 14 [/SUP], Ewen Harrison[SUP] 15 [/SUP], Annemarie B Docherty[SUP] 15 [/SUP], Nazir I Lone[SUP] 15 [/SUP], Jennifer Kathleen Quint[SUP] 16 [/SUP], James Chalmers[SUP] 17 [/SUP], Ling-Pei Ho[SUP] 18 [/SUP], Alex Horsley[SUP] 19 [/SUP], Michael Marks[SUP] 20 [/SUP], Krisnah Poinasamy[SUP] 21 [/SUP], Rachael Evans[SUP] 22 [/SUP], Louise V Wain[SUP] 13 [/SUP], Chris Brightling[SUP] 22 [/SUP], Gerry P McCann[SUP] 23 [/SUP]; PHOSP-COVID Study Collaborative Group
Collaborators, Affiliations
Background: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.
Methods: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.
Results: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).
Conclusion: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.
Trail registration number: ISRCTN10980107.
Keywords: CARDIAC REHABILITATION; COVID-19; RISK FACTORS.
. 2024 May 27;11(1):e002662.
doi: 10.1136/openhrt-2024-002662. Long COVID and cardiovascular disease: a prospective cohort study
Claire Alexandra Lawson[SUP] 1 [/SUP], Alastair James Moss[SUP] 1 [/SUP], Jayanth Ranjit Arnold[SUP] 1 [/SUP], Catherine Bagot[SUP] 2 [/SUP], Amitava Banerjee[SUP] 3 [/SUP], Colin Berry[SUP] 4 5 [/SUP], John Greenwood[SUP] 6 7 [/SUP], Alun D Hughes[SUP] 8 [/SUP], Kamlesh Khunti[SUP] 9 [/SUP], Nicholas L Mills[SUP] 10 [/SUP], Stefan Neubauer[SUP] 11 [/SUP], Betty Raman[SUP] 11 [/SUP], Naveed Sattar[SUP] 12 [/SUP], Olivia C Leavy[SUP] 13 [/SUP], Matthew Richardson[SUP] 14 [/SUP], Omer Elneima[SUP] 14 [/SUP], Hamish Jc McAuley[SUP] 14 [/SUP], Aarti Shikotra[SUP] 14 [/SUP], Amisha Singapuri[SUP] 14 [/SUP], Marco Sereno[SUP] 14 [/SUP], Ruth Saunders[SUP] 14 [/SUP], Victoria Harris[SUP] 14 [/SUP], Linzy Houchen-Wolloff[SUP] 14 [/SUP], Neil J Greening[SUP] 14 [/SUP], Ewen Harrison[SUP] 15 [/SUP], Annemarie B Docherty[SUP] 15 [/SUP], Nazir I Lone[SUP] 15 [/SUP], Jennifer Kathleen Quint[SUP] 16 [/SUP], James Chalmers[SUP] 17 [/SUP], Ling-Pei Ho[SUP] 18 [/SUP], Alex Horsley[SUP] 19 [/SUP], Michael Marks[SUP] 20 [/SUP], Krisnah Poinasamy[SUP] 21 [/SUP], Rachael Evans[SUP] 22 [/SUP], Louise V Wain[SUP] 13 [/SUP], Chris Brightling[SUP] 22 [/SUP], Gerry P McCann[SUP] 23 [/SUP]; PHOSP-COVID Study Collaborative Group
Collaborators, Affiliations
- PMID: 38802280
- DOI: 10.1136/openhrt-2024-002662
Background: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.
Methods: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.
Results: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).
Conclusion: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.
Trail registration number: ISRCTN10980107.
Keywords: CARDIAC REHABILITATION; COVID-19; RISK FACTORS.