tetano
Editor, Senior Moderator
Open Heart
. 2025 Jul 18;12(2):e003333.
doi: 10.1136/openhrt-2025-003333. Improved diagnosis of COVID-19 vaccine-associated myocarditis with cardiac scarring identified by cardiac magnetic resonance imaging
Josephine Warren[SUP] 1 2 [/SUP], Daryl Cheng[SUP] 3 4 5 6 [/SUP], Nigel Crawford[SUP] 3 4 6 [/SUP], Bryn Jones[SUP] 6 7 8 [/SUP], Rui Lun Ng[SUP] 7 [/SUP], Annette Alafaci[SUP] 4 [/SUP], Dion Stub[SUP] 1 9 [/SUP], Philip Lew[SUP] 10 [/SUP], Andrew J Taylor[SUP] 11 12 [/SUP]
Affiliations
Background: Myocarditis is a rare but potentially serious complication of COVID-19 vaccination. Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging can identify cardiac scar, which may improve diagnostic accuracy and prognostication. We sought to define the incidence of long-term LGE post COVID-19 vaccine-associated myocarditis (C-VAM) and to establish the additive role of CMR in the diagnostic workup of this condition.
Methods: Patients with Brighton Collaboration Criteria Level 1 (definite) or Level 2 (probable) C-VAM were prospectively recruited from the Surveillance of Adverse Events Following Vaccination In the Community database to undergo CMR at least 6 months after diagnosis. As there were limited patients with access to baseline CMR, prior CMR results were not included in the initial case definition. The presence of LGE at follow-up CMR was then integrated into the diagnostic algorithm, and the reclassification rate (definite vs probable) was calculated.
Results: 67 patients with C-VAM (mean age 30±13 years, 72% male) underwent CMR evaluation. The median time from vaccination to CMR was 548 (range 398-603) days. 20 patients (30%) had LGE. At diagnosis, nine patients (13%) were classified as definite and 58 (87%) as probable myocarditis. With the integration of CMR-LGE data, 16 patients (28%) were reclassified from probable to definite myocarditis.
Conclusion: LGE on CMR occurred in one-third of patients with C-VAM. Without CMR at the time of diagnosis, almost one-third of patients are misclassified as probable rather than definite myocarditis, indicating a diagnostic strategy using echocardiography alone is insufficient.
Keywords: COVID-19; MYOCARDIAL FIBROSIS; Myocarditis.
. 2025 Jul 18;12(2):e003333.
doi: 10.1136/openhrt-2025-003333. Improved diagnosis of COVID-19 vaccine-associated myocarditis with cardiac scarring identified by cardiac magnetic resonance imaging
Josephine Warren[SUP] 1 2 [/SUP], Daryl Cheng[SUP] 3 4 5 6 [/SUP], Nigel Crawford[SUP] 3 4 6 [/SUP], Bryn Jones[SUP] 6 7 8 [/SUP], Rui Lun Ng[SUP] 7 [/SUP], Annette Alafaci[SUP] 4 [/SUP], Dion Stub[SUP] 1 9 [/SUP], Philip Lew[SUP] 10 [/SUP], Andrew J Taylor[SUP] 11 12 [/SUP]
Affiliations
- PMID: 40681307
- DOI: 10.1136/openhrt-2025-003333
Background: Myocarditis is a rare but potentially serious complication of COVID-19 vaccination. Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging can identify cardiac scar, which may improve diagnostic accuracy and prognostication. We sought to define the incidence of long-term LGE post COVID-19 vaccine-associated myocarditis (C-VAM) and to establish the additive role of CMR in the diagnostic workup of this condition.
Methods: Patients with Brighton Collaboration Criteria Level 1 (definite) or Level 2 (probable) C-VAM were prospectively recruited from the Surveillance of Adverse Events Following Vaccination In the Community database to undergo CMR at least 6 months after diagnosis. As there were limited patients with access to baseline CMR, prior CMR results were not included in the initial case definition. The presence of LGE at follow-up CMR was then integrated into the diagnostic algorithm, and the reclassification rate (definite vs probable) was calculated.
Results: 67 patients with C-VAM (mean age 30±13 years, 72% male) underwent CMR evaluation. The median time from vaccination to CMR was 548 (range 398-603) days. 20 patients (30%) had LGE. At diagnosis, nine patients (13%) were classified as definite and 58 (87%) as probable myocarditis. With the integration of CMR-LGE data, 16 patients (28%) were reclassified from probable to definite myocarditis.
Conclusion: LGE on CMR occurred in one-third of patients with C-VAM. Without CMR at the time of diagnosis, almost one-third of patients are misclassified as probable rather than definite myocarditis, indicating a diagnostic strategy using echocardiography alone is insufficient.
Keywords: COVID-19; MYOCARDIAL FIBROSIS; Myocarditis.