tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 May 20;8(6)
fab164.
doi: 10.1093/ofid/ofab164. eCollection 2021 Jun.
Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
Rachel L Epstein[SUP] 1 [/SUP], Heather Sperring[SUP] 2 [/SUP], Melissa Hofman[SUP] 3 [/SUP], Sara Lodi[SUP] 4 [/SUP], Laura F White[SUP] 4 [/SUP], Joshua A Barocas[SUP] 1 [/SUP], Tara C Bouton[SUP] 1 [/SUP], Yian Xiao[SUP] 5 [/SUP], Heather E Hsu[SUP] 6 [/SUP], Nancy S Miller[SUP] 7 [/SUP], Benjamin P Linas[SUP] 1 [/SUP], Jai G Marathe[SUP] 1 [/SUP]
Affiliations
Abstract
To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.
Keywords: SARS-CoV-2; coronavirus disease 2019 (COVID-19); disease severity; immunocompromised host; immunosuppression; polymerase chain reaction; virus shedding.
. 2021 May 20;8(6)
fab164.doi: 10.1093/ofid/ofab164. eCollection 2021 Jun.
Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
Rachel L Epstein[SUP] 1 [/SUP], Heather Sperring[SUP] 2 [/SUP], Melissa Hofman[SUP] 3 [/SUP], Sara Lodi[SUP] 4 [/SUP], Laura F White[SUP] 4 [/SUP], Joshua A Barocas[SUP] 1 [/SUP], Tara C Bouton[SUP] 1 [/SUP], Yian Xiao[SUP] 5 [/SUP], Heather E Hsu[SUP] 6 [/SUP], Nancy S Miller[SUP] 7 [/SUP], Benjamin P Linas[SUP] 1 [/SUP], Jai G Marathe[SUP] 1 [/SUP]
Affiliations
- PMID: 34189164
- PMCID: PMC8231388
- DOI: 10.1093/ofid/ofab164
Abstract
To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.
Keywords: SARS-CoV-2; coronavirus disease 2019 (COVID-19); disease severity; immunocompromised host; immunosuppression; polymerase chain reaction; virus shedding.