tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jul 6;8(7)
fab279.
doi: 10.1093/ofid/ofab279. eCollection 2021 Jul.
Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children
Nathella Pavan Kumar[SUP] 1 [/SUP], Aishwarya Venkataraman[SUP] 1 2 [/SUP], Luke Elizabeth Hanna[SUP] 1 [/SUP], Sulochana Putlibai[SUP] 2 [/SUP], M Karthick[SUP] 1 [/SUP], Anuradha Rajamanikam[SUP] 3 [/SUP], Kalaimaran Sadasivam[SUP] 2 [/SUP], Balasubramanian Sundaram[SUP] 2 [/SUP], Subash Babu[SUP] 3 4 [/SUP]
Affiliations
Abstract
Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that can result in increased morbidity and mortality. The inflammatory underpinnings of MIS-C have not been examined in detail.
Methods: We examined the plasma levels of acute phase proteins and microbial translocation markers in children with MIS-C, children with acute coronavirus disease 2019 (COVID-19) infection, SARS-CoV-2-seropositive children, and controls.
Results: MIS-C children exhibited significantly higher levels of C-reactive protein (CRP), alpha2 macroglobulin (α2M), serum amyloid P (SAP), lipopolysaccharide (LPS), sCD14, and LPS binding protein (LBP) and significantly lower levels of haptoglobin (Hp) in comparison with seropositive, control, and/or COVID-19 children. In addition, COVID-19 children exhibited significantly higher levels of most of the above markers in comparison with seropositive and control children. Principal component analysis using a set of these markers could clearly discriminate MIS-C and COVID-19 from seropositive and control children. MIS-C children requiring pediatric intensive care unit admission and COVID-19 children with severe disease had higher levels of CRP, SAP, and/or sCD14 at admission.
Conclusions: Our study describes the role of systemic inflammation and microbial translocation markers in children with MIS-C and COVID-19 and therefore helps in advancing our understanding of the pathogenesis of different presentations of SARS-CoV-2 infection in children.
Keywords: COVID-19; MIS-C; acute phase proteins; biomarkers; microbial translocation; seropositive.
. 2021 Jul 6;8(7)
fab279.doi: 10.1093/ofid/ofab279. eCollection 2021 Jul.
Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children
Nathella Pavan Kumar[SUP] 1 [/SUP], Aishwarya Venkataraman[SUP] 1 2 [/SUP], Luke Elizabeth Hanna[SUP] 1 [/SUP], Sulochana Putlibai[SUP] 2 [/SUP], M Karthick[SUP] 1 [/SUP], Anuradha Rajamanikam[SUP] 3 [/SUP], Kalaimaran Sadasivam[SUP] 2 [/SUP], Balasubramanian Sundaram[SUP] 2 [/SUP], Subash Babu[SUP] 3 4 [/SUP]
Affiliations
- PMID: 34322566
- PMCID: PMC8312521
- DOI: 10.1093/ofid/ofab279
Abstract
Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that can result in increased morbidity and mortality. The inflammatory underpinnings of MIS-C have not been examined in detail.
Methods: We examined the plasma levels of acute phase proteins and microbial translocation markers in children with MIS-C, children with acute coronavirus disease 2019 (COVID-19) infection, SARS-CoV-2-seropositive children, and controls.
Results: MIS-C children exhibited significantly higher levels of C-reactive protein (CRP), alpha2 macroglobulin (α2M), serum amyloid P (SAP), lipopolysaccharide (LPS), sCD14, and LPS binding protein (LBP) and significantly lower levels of haptoglobin (Hp) in comparison with seropositive, control, and/or COVID-19 children. In addition, COVID-19 children exhibited significantly higher levels of most of the above markers in comparison with seropositive and control children. Principal component analysis using a set of these markers could clearly discriminate MIS-C and COVID-19 from seropositive and control children. MIS-C children requiring pediatric intensive care unit admission and COVID-19 children with severe disease had higher levels of CRP, SAP, and/or sCD14 at admission.
Conclusions: Our study describes the role of systemic inflammation and microbial translocation markers in children with MIS-C and COVID-19 and therefore helps in advancing our understanding of the pathogenesis of different presentations of SARS-CoV-2 infection in children.
Keywords: COVID-19; MIS-C; acute phase proteins; biomarkers; microbial translocation; seropositive.