tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jun 30;8(7)
fab353.
doi: 10.1093/ofid/ofab353. eCollection 2021 Jul.
Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era
Mounzer E Agha[SUP] 1 [/SUP], Maggie Blake[SUP] 1 [/SUP], Charles Chilleo[SUP] 2 [/SUP], Alan Wells[SUP] 3 [/SUP], Ghady Haidar[SUP] 4 [/SUP]
Affiliations
Abstract
We measured severe acute respiratory syndrome coronavirus 2 immunoglobulin G responses in 67 patients with hematological malignancies after 2 messenger RNA vaccine doses. Forty-six percent were nonresponders; patients with B-cell chronic lymphocytic leukemia were at highest risk (77% nonresponders). Patients with hematological malignancies should continue wearing masks and socially distancing. Studies of revaccination, boosters, and humoral immune correlates of protection are needed.
Keywords: 19 vaccine; 2; COVID; CoV; SARS; antibody; hematological malignancy.
. 2021 Jun 30;8(7)
fab353.doi: 10.1093/ofid/ofab353. eCollection 2021 Jul.
Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era
Mounzer E Agha[SUP] 1 [/SUP], Maggie Blake[SUP] 1 [/SUP], Charles Chilleo[SUP] 2 [/SUP], Alan Wells[SUP] 3 [/SUP], Ghady Haidar[SUP] 4 [/SUP]
Affiliations
- PMID: 34337100
- PMCID: PMC8320282
- DOI: 10.1093/ofid/ofab353
Abstract
We measured severe acute respiratory syndrome coronavirus 2 immunoglobulin G responses in 67 patients with hematological malignancies after 2 messenger RNA vaccine doses. Forty-six percent were nonresponders; patients with B-cell chronic lymphocytic leukemia were at highest risk (77% nonresponders). Patients with hematological malignancies should continue wearing masks and socially distancing. Studies of revaccination, boosters, and humoral immune correlates of protection are needed.
Keywords: 19 vaccine; 2; COVID; CoV; SARS; antibody; hematological malignancy.