Open Forum Infect Dis . Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Pe

[tetano]

Open Forum Infect Dis


. 2023 Feb 3;10(2)fad054.
doi: 10.1093/ofid/ofad054. eCollection 2023 Feb.
Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV


Dara Khosravi[SUP] 1 [/SUP], Hannah Soloff[SUP] 2 [/SUP], Rose M Langsjoen[SUP] 1 [/SUP], Andrei Bombin[SUP] 1 [/SUP], Colleen F Kelley[SUP] 3 [/SUP], Susan M Ray[SUP] 3 [/SUP], Clifford J Gunthel[SUP] 3 [/SUP], Brian C Zanoni[SUP] 3 4 [/SUP], Phuong-Vi Nguyen[SUP] 3 [/SUP], Jesse J Waggoner[SUP] 3 [/SUP], Yun F Wang[SUP] 1 [/SUP], Valeria D Cantos[SUP] 3 [/SUP], Anne Piantadosi[SUP] 1 3 [/SUP]



Affiliations

• PMID: 36820315
• PMCID: PMC9938522
• DOI: 10.1093/ofid/ofad054

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.

Keywords: HIV; SARS-CoV-2; immunocompromised; monoclonal antibody; virus evolution.