tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Jul 3;10(7)
fad340.
doi: 10.1093/ofid/ofad340. eCollection 2023 Jul. Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France
Alix De Thoisy[SUP] 1 [/SUP], Tom Woudenberg[SUP] 1 [/SUP], Stéphane Pelleau[SUP] 1 [/SUP], Françoise Donnadieu[SUP] 1 [/SUP], Laura Garcia[SUP] 1 [/SUP], Laurie Pinaud[SUP] 2 [/SUP], Laura Tondeur[SUP] 2 [/SUP], Annalisa Meola[SUP] 3 [/SUP], Laurence Arowas[SUP] 4 [/SUP], Nathalie Clement[SUP] 5 [/SUP], Marija Backovic[SUP] 3 [/SUP], Marie-Noëlle Ungeheuer[SUP] 4 [/SUP], Arnaud Fontanet[SUP] 2 6 [/SUP], Michael White[SUP] 1 [/SUP]; COVID-Oise and SeroPed study teams
Collaborators, Affiliations
Background: The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed.
Methods: In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay.
Results: The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 year[SUP]-1[/SUP] for children, and 0.13-0.27 year[SUP]-1[/SUP] for adults. Seroreversion was estimated as 0.31-1.37 year[SUP]-1[/SUP] in children and 0.19-0.72 year[SUP]-1[/SUP] in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV.
Conclusions: The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children.
Keywords: epidemiology; seasonal human coronavirus; serocatalytic model; serology.
. 2023 Jul 3;10(7)
fad340.doi: 10.1093/ofid/ofad340. eCollection 2023 Jul. Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France
Alix De Thoisy[SUP] 1 [/SUP], Tom Woudenberg[SUP] 1 [/SUP], Stéphane Pelleau[SUP] 1 [/SUP], Françoise Donnadieu[SUP] 1 [/SUP], Laura Garcia[SUP] 1 [/SUP], Laurie Pinaud[SUP] 2 [/SUP], Laura Tondeur[SUP] 2 [/SUP], Annalisa Meola[SUP] 3 [/SUP], Laurence Arowas[SUP] 4 [/SUP], Nathalie Clement[SUP] 5 [/SUP], Marija Backovic[SUP] 3 [/SUP], Marie-Noëlle Ungeheuer[SUP] 4 [/SUP], Arnaud Fontanet[SUP] 2 6 [/SUP], Michael White[SUP] 1 [/SUP]; COVID-Oise and SeroPed study teams
Collaborators, Affiliations
- PMID: 37496603
- PMCID: PMC10368309
- DOI: 10.1093/ofid/ofad340
Background: The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed.
Methods: In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay.
Results: The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 year[SUP]-1[/SUP] for children, and 0.13-0.27 year[SUP]-1[/SUP] for adults. Seroreversion was estimated as 0.31-1.37 year[SUP]-1[/SUP] in children and 0.19-0.72 year[SUP]-1[/SUP] in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV.
Conclusions: The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children.
Keywords: epidemiology; seasonal human coronavirus; serocatalytic model; serology.