tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2020 Dec 28;8(2)
faa638.
doi: 10.1093/ofid/ofaa638. eCollection 2021 Feb.
Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19-United States, March-September 2020
Audrey F Pennington[SUP] 1 [/SUP], Lyudmyla Kompaniyets[SUP] 1 [/SUP], April D Summers[SUP] 1 [/SUP], Melissa L Danielson[SUP] 1 [/SUP], Alyson B Goodman[SUP] 1 2 [/SUP], Jennifer R Chevinsky[SUP] 1 [/SUP], Leigh Ellyn Preston[SUP] 1 [/SUP], Lyna Z Schieber[SUP] 1 [/SUP], Gonza Namulanda[SUP] 1 [/SUP], Joseph Courtney[SUP] 1 [/SUP], Heather M Strosnider[SUP] 1 [/SUP], Tegan K Boehmer[SUP] 1 2 [/SUP], William R Mac Kenzie[SUP] 1 2 [/SUP], James Baggs[SUP] 1 [/SUP], Adi V Gundlapalli[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths.
Methods: Using data from the Premier Healthcare Database on 181813 hospitalized adults diagnosed with COVID-19 during March-September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity.
Results: Overall, 84497 (47%) patients were admitted to the ICU, 29078 (16%) received IMV, and 27864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92-0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09-1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09-1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06-1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups.
Conclusions: These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes.
Keywords: 2019 novel coronavirus disease; adult; health care disparities; mortality; race/ethnicity.
. 2020 Dec 28;8(2)
faa638.doi: 10.1093/ofid/ofaa638. eCollection 2021 Feb.
Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19-United States, March-September 2020
Audrey F Pennington[SUP] 1 [/SUP], Lyudmyla Kompaniyets[SUP] 1 [/SUP], April D Summers[SUP] 1 [/SUP], Melissa L Danielson[SUP] 1 [/SUP], Alyson B Goodman[SUP] 1 2 [/SUP], Jennifer R Chevinsky[SUP] 1 [/SUP], Leigh Ellyn Preston[SUP] 1 [/SUP], Lyna Z Schieber[SUP] 1 [/SUP], Gonza Namulanda[SUP] 1 [/SUP], Joseph Courtney[SUP] 1 [/SUP], Heather M Strosnider[SUP] 1 [/SUP], Tegan K Boehmer[SUP] 1 2 [/SUP], William R Mac Kenzie[SUP] 1 2 [/SUP], James Baggs[SUP] 1 [/SUP], Adi V Gundlapalli[SUP] 1 [/SUP]
Affiliations
- PMID: 33553477
- PMCID: PMC7798738
- DOI: 10.1093/ofid/ofaa638
Abstract
Background: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths.
Methods: Using data from the Premier Healthcare Database on 181813 hospitalized adults diagnosed with COVID-19 during March-September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity.
Results: Overall, 84497 (47%) patients were admitted to the ICU, 29078 (16%) received IMV, and 27864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92-0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09-1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09-1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06-1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups.
Conclusions: These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes.
Keywords: 2019 novel coronavirus disease; adult; health care disparities; mortality; race/ethnicity.