tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2024 Jan 23;11(2)
fae039.
doi: 10.1093/ofid/ofae039. eCollection 2024 Feb. Reduction in Long COVID Symptoms and Symptom Severity in Vaccinated Compared to Unvaccinated Adults
Hannah E Maier[SUP] 1 [/SUP], Theresa Kowalski-Dobson[SUP] 1 [/SUP], Ashley Eckard[SUP] 1 [/SUP], Carmen Gherasim[SUP] 2 [/SUP], David Manthei[SUP] 2 [/SUP], Alyssa Meyers[SUP] 1 [/SUP], Dawson Davis[SUP] 2 [/SUP], Kevin Bakker[SUP] 1 [/SUP], Kathleen Lindsey[SUP] 1 [/SUP], Zijin Chu[SUP] 1 [/SUP], Lauren Warsinske[SUP] 1 [/SUP], Matthew Arnold[SUP] 1 [/SUP], Anna Buswinka[SUP] 1 [/SUP], Emily Stoneman[SUP] 3 [/SUP], Riccardo Valdez[SUP] 2 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
Background: The impact of vaccination prior to infection on postacute sequelae of coronavirus disease 2019 (COVID-19, PASC), also known as long COVID, remains unclear. Here we assess the protective effect of vaccination on long COVID in a community-based setting.
Methods: The Immunity Associated with SARS-CoV-2 (IASO) study is an ongoing prospective cohort of working adults that began in October 2020. Participants are actively followed for severe acute respiratory syndrome coronavirus 2 infection. We compared the prevalence of symptoms and symptom severity in vaccinated compared to unvaccinated cases. Our primary definition of long COVID was the presence of symptoms at 90 days postinfection; 30 days postinfection was also examined.
Results: Overall, by 90 days postinfection, 13% of cases had long COVID, with 27% of unvaccinated cases and 8% of vaccinated cases reporting long COVID (relative risk [RR], 0.31 [95% confidence interval {CI}, .22-.42]). Vaccination was also associated with significantly lower average severity scores at all timepoints (eg, relative severity at 90 days postinfection: -2.70 [95% CI, -1.68 to -3.73]). In the pre-Omicron era, 28% of unvaccinated cases and 18% of vaccinated cases reported long COVID (P = .07), and vaccinated cases reported less severe symptoms including less difficulty breathing (P = .01; 90-day RR, 0.07).
Conclusions: Vaccinated cases had lower prevalence of long COVID and reduced symptom severity.
Keywords: COVID-19; SARS-CoV-2; community-based; long COVID; vaccine.
. 2024 Jan 23;11(2)
fae039.doi: 10.1093/ofid/ofae039. eCollection 2024 Feb. Reduction in Long COVID Symptoms and Symptom Severity in Vaccinated Compared to Unvaccinated Adults
Hannah E Maier[SUP] 1 [/SUP], Theresa Kowalski-Dobson[SUP] 1 [/SUP], Ashley Eckard[SUP] 1 [/SUP], Carmen Gherasim[SUP] 2 [/SUP], David Manthei[SUP] 2 [/SUP], Alyssa Meyers[SUP] 1 [/SUP], Dawson Davis[SUP] 2 [/SUP], Kevin Bakker[SUP] 1 [/SUP], Kathleen Lindsey[SUP] 1 [/SUP], Zijin Chu[SUP] 1 [/SUP], Lauren Warsinske[SUP] 1 [/SUP], Matthew Arnold[SUP] 1 [/SUP], Anna Buswinka[SUP] 1 [/SUP], Emily Stoneman[SUP] 3 [/SUP], Riccardo Valdez[SUP] 2 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
- PMID: 38328496
- PMCID: PMC10847810
- DOI: 10.1093/ofid/ofae039
Background: The impact of vaccination prior to infection on postacute sequelae of coronavirus disease 2019 (COVID-19, PASC), also known as long COVID, remains unclear. Here we assess the protective effect of vaccination on long COVID in a community-based setting.
Methods: The Immunity Associated with SARS-CoV-2 (IASO) study is an ongoing prospective cohort of working adults that began in October 2020. Participants are actively followed for severe acute respiratory syndrome coronavirus 2 infection. We compared the prevalence of symptoms and symptom severity in vaccinated compared to unvaccinated cases. Our primary definition of long COVID was the presence of symptoms at 90 days postinfection; 30 days postinfection was also examined.
Results: Overall, by 90 days postinfection, 13% of cases had long COVID, with 27% of unvaccinated cases and 8% of vaccinated cases reporting long COVID (relative risk [RR], 0.31 [95% confidence interval {CI}, .22-.42]). Vaccination was also associated with significantly lower average severity scores at all timepoints (eg, relative severity at 90 days postinfection: -2.70 [95% CI, -1.68 to -3.73]). In the pre-Omicron era, 28% of unvaccinated cases and 18% of vaccinated cases reported long COVID (P = .07), and vaccinated cases reported less severe symptoms including less difficulty breathing (P = .01; 90-day RR, 0.07).
Conclusions: Vaccinated cases had lower prevalence of long COVID and reduced symptom severity.
Keywords: COVID-19; SARS-CoV-2; community-based; long COVID; vaccine.