tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 Dec 15;10(1)
fac677.
doi: 10.1093/ofid/ofac677. eCollection 2023 Jan.
Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients
Santosh Dhakal[SUP] 1 [/SUP], Tong Yu[SUP] 2 [/SUP], Anna Yin[SUP] 1 [/SUP], Nora Pisanic[SUP] 3 [/SUP], Zoe O Demko[SUP] 2 [/SUP], Annukka A R Antar[SUP] 2 [/SUP], Andrea L Cox[SUP] 2 [/SUP], Christopher D Heaney[SUP] 3 4 5 [/SUP], Yukari C Manabe[SUP] 1 2 5 [/SUP], Sabra L Klein[SUP] 1 2 5 [/SUP]
Affiliations
Abstract
Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.
Keywords: COVID-19; hybrid immunity; nucleocapsid antibody; surveillance; vaccines.
. 2022 Dec 15;10(1)
fac677.doi: 10.1093/ofid/ofac677. eCollection 2023 Jan.
Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients
Santosh Dhakal[SUP] 1 [/SUP], Tong Yu[SUP] 2 [/SUP], Anna Yin[SUP] 1 [/SUP], Nora Pisanic[SUP] 3 [/SUP], Zoe O Demko[SUP] 2 [/SUP], Annukka A R Antar[SUP] 2 [/SUP], Andrea L Cox[SUP] 2 [/SUP], Christopher D Heaney[SUP] 3 4 5 [/SUP], Yukari C Manabe[SUP] 1 2 5 [/SUP], Sabra L Klein[SUP] 1 2 5 [/SUP]
Affiliations
- PMID: 36655185
- PMCID: PMC9835753
- DOI: 10.1093/ofid/ofac677
Abstract
Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.
Keywords: COVID-19; hybrid immunity; nucleocapsid antibody; surveillance; vaccines.