tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 Mar 16;9(5)
fac131.
doi: 10.1093/ofid/ofac131. eCollection 2022 May.
Rates of Severe Influenza-Associated Outcomes Among Older Adults Living With Diabetes-Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012-2017
Daniel Owusu[SUP] 1 2 [/SUP], Melissa A Rolfes[SUP] 2 [/SUP], Carmen S Arriola[SUP] 2 [/SUP], Pam Daily Kirley[SUP] 3 [/SUP], Nisha B Alden[SUP] 4 [/SUP], James Meek[SUP] 5 [/SUP], Evan J Anderson[SUP] 6 7 8 [/SUP], Maya L Monroe[SUP] 9 [/SUP], Sue Kim[SUP] 10 [/SUP], Ruth Lynfield[SUP] 11 [/SUP], Kathy Angeles[SUP] 12 [/SUP], Nancy Spina[SUP] 13 [/SUP], Christina B Felsen[SUP] 14 [/SUP], Laurie Billing[SUP] 15 [/SUP], Ann Thomas[SUP] 16 [/SUP], H Keipp Talbot[SUP] 17 [/SUP], William Schaffner[SUP] 17 [/SUP], Ryan Chatelain[SUP] 18 [/SUP], Carrie Reed[SUP] 2 [/SUP], Shikha Garg[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Diabetes mellitus (DM) is common among older adults hospitalized with influenza, yet data are limited on the impact of DM on risk of severe influenza-associated outcomes.
Methods: We included adults aged ≥65 years hospitalized with influenza during 2012-2013 through 2016-2017 from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance system for laboratory-confirmed influenza-associated hospitalizations conducted in defined counties within 13 states. We calculated population denominators using the Centers for Medicare and Medicaid Services county-specific DM prevalence estimates and National Center for Health Statistics population data. We present pooled rates and rate ratios (RRs) of intensive care unit (ICU) admission, pneumonia diagnosis, mechanical ventilation, and in-hospital death for persons with and without DM. We estimated RRs and 95% confidence intervals (CIs) using meta-analysis with site as a random effect in order to control for site differences in the estimates.
Results: Of 31 934 hospitalized adults included in the analysis, 34% had DM. Compared to those without DM, adults with DM had higher rates of influenza-associated hospitalization (RR, 1.57 [95% CI, 1.43-1.72]), ICU admission (RR, 1.84 [95% CI, 1.67-2.04]), pneumonia (RR, 1.57 [95% CI, 1.42-1.73]), mechanical ventilation (RR, 1.95 [95% CI, 1.74-2.20]), and in-hospital death (RR, 1.48 [95% CI, 1.23-1.80]).
Conclusions: Older adults with DM have higher rates of severe influenza-associated outcomes compared to those without DM. These findings reinforce the importance of preventing influenza virus infections through annual vaccination, and early treatment of influenza illness with antivirals in older adults with DM.
Keywords: diabetes mellitus; influenza; influenza hospitalization; severe influenza outcomes.
. 2022 Mar 16;9(5)
fac131.doi: 10.1093/ofid/ofac131. eCollection 2022 May.
Rates of Severe Influenza-Associated Outcomes Among Older Adults Living With Diabetes-Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012-2017
Daniel Owusu[SUP] 1 2 [/SUP], Melissa A Rolfes[SUP] 2 [/SUP], Carmen S Arriola[SUP] 2 [/SUP], Pam Daily Kirley[SUP] 3 [/SUP], Nisha B Alden[SUP] 4 [/SUP], James Meek[SUP] 5 [/SUP], Evan J Anderson[SUP] 6 7 8 [/SUP], Maya L Monroe[SUP] 9 [/SUP], Sue Kim[SUP] 10 [/SUP], Ruth Lynfield[SUP] 11 [/SUP], Kathy Angeles[SUP] 12 [/SUP], Nancy Spina[SUP] 13 [/SUP], Christina B Felsen[SUP] 14 [/SUP], Laurie Billing[SUP] 15 [/SUP], Ann Thomas[SUP] 16 [/SUP], H Keipp Talbot[SUP] 17 [/SUP], William Schaffner[SUP] 17 [/SUP], Ryan Chatelain[SUP] 18 [/SUP], Carrie Reed[SUP] 2 [/SUP], Shikha Garg[SUP] 2 [/SUP]
Affiliations
- PMID: 35450083
- PMCID: PMC9017364
- DOI: 10.1093/ofid/ofac131
Abstract
Background: Diabetes mellitus (DM) is common among older adults hospitalized with influenza, yet data are limited on the impact of DM on risk of severe influenza-associated outcomes.
Methods: We included adults aged ≥65 years hospitalized with influenza during 2012-2013 through 2016-2017 from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance system for laboratory-confirmed influenza-associated hospitalizations conducted in defined counties within 13 states. We calculated population denominators using the Centers for Medicare and Medicaid Services county-specific DM prevalence estimates and National Center for Health Statistics population data. We present pooled rates and rate ratios (RRs) of intensive care unit (ICU) admission, pneumonia diagnosis, mechanical ventilation, and in-hospital death for persons with and without DM. We estimated RRs and 95% confidence intervals (CIs) using meta-analysis with site as a random effect in order to control for site differences in the estimates.
Results: Of 31 934 hospitalized adults included in the analysis, 34% had DM. Compared to those without DM, adults with DM had higher rates of influenza-associated hospitalization (RR, 1.57 [95% CI, 1.43-1.72]), ICU admission (RR, 1.84 [95% CI, 1.67-2.04]), pneumonia (RR, 1.57 [95% CI, 1.42-1.73]), mechanical ventilation (RR, 1.95 [95% CI, 1.74-2.20]), and in-hospital death (RR, 1.48 [95% CI, 1.23-1.80]).
Conclusions: Older adults with DM have higher rates of severe influenza-associated outcomes compared to those without DM. These findings reinforce the importance of preventing influenza virus infections through annual vaccination, and early treatment of influenza illness with antivirals in older adults with DM.
Keywords: diabetes mellitus; influenza; influenza hospitalization; severe influenza outcomes.