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Open Forum Infect Dis . Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Prelimina

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2023 Aug 31;10(10):ofad451.
doi: 10.1093/ofid/ofad451. eCollection 2023 Oct. Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report

Lindsay Wilson[SUP] 1 [/SUP], Ju-Wei Chang[SUP] 1 [/SUP], Stuart Meier[SUP] 1 [/SUP], Tariq Ganief[SUP] 2 3 [/SUP], Naadir Ganief[SUP] 2 3 [/SUP], Suzette Oelofse[SUP] 1 [/SUP], Vicky Baillie[SUP] 4 5 [/SUP], Marta C Nunes[SUP] 4 5 [/SUP], Shabir A Madhi[SUP] 4 5 6 [/SUP], Jonathan Blackburn[SUP] 2 3 [/SUP], Keertan Dheda[SUP] 1 7 [/SUP]



Affiliations
Abstract

The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls.

Keywords: hospitalized; pathogenesis; pneumonia.

 
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