tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2025 Apr 10;12(5)
faf210.
doi: 10.1093/ofid/ofaf210. eCollection 2025 May. Proportions of US Blood Donors With Serological Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections Who Reported Survey-Based Diagnosed Infections During July 2020-December 2022
Akintunde Akinseye[SUP] 1 [/SUP], David J Wright[SUP] 1 [/SUP], Eduard Grebe[SUP] 2 [/SUP], Mars Stone[SUP] 2 3 [/SUP], Cassandra A Hathaway[SUP] 1 [/SUP], Rebecca V Fink[SUP] 1 [/SUP], Bryan R Spencer[SUP] 4 [/SUP], Paula Saa[SUP] 4 [/SUP], Marion C Lanteri[SUP] 2 5 [/SUP], Michael Busch[SUP] 2 3 [/SUP], Jefferson M Jones[SUP] 6 [/SUP]
Affiliations
The proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections diagnosed by coronavirus disease 2019 (COVID-19) tests, including home antigen tests, is unknown. We detected infections among blood donors in the United States (US) by testing for nucleocapsid antibody (anti-N) seroconversion and administered a questionnaire to determine the proportion of those infections that were associated with a self-reported positive COVID-19 test. Among US blood donors with serologic evidence of SARS-CoV-2 infection who completed a survey, 47.7% reported an associated self-reported positive COVID-19 test. This proportion changed from July-December 2020 (44.9%) to July-December 2022 (54.8%). This study suggests many SARS-CoV-2 infections in adults are not diagnosed with a test.
Keywords: COVID-19; SARS-CoV-2; antibody assay; blood donors; viral tests.
. 2025 Apr 10;12(5)
faf210.doi: 10.1093/ofid/ofaf210. eCollection 2025 May. Proportions of US Blood Donors With Serological Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections Who Reported Survey-Based Diagnosed Infections During July 2020-December 2022
Akintunde Akinseye[SUP] 1 [/SUP], David J Wright[SUP] 1 [/SUP], Eduard Grebe[SUP] 2 [/SUP], Mars Stone[SUP] 2 3 [/SUP], Cassandra A Hathaway[SUP] 1 [/SUP], Rebecca V Fink[SUP] 1 [/SUP], Bryan R Spencer[SUP] 4 [/SUP], Paula Saa[SUP] 4 [/SUP], Marion C Lanteri[SUP] 2 5 [/SUP], Michael Busch[SUP] 2 3 [/SUP], Jefferson M Jones[SUP] 6 [/SUP]
Affiliations
- PMID: 40302721
- PMCID: PMC12039488
- DOI: 10.1093/ofid/ofaf210
The proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections diagnosed by coronavirus disease 2019 (COVID-19) tests, including home antigen tests, is unknown. We detected infections among blood donors in the United States (US) by testing for nucleocapsid antibody (anti-N) seroconversion and administered a questionnaire to determine the proportion of those infections that were associated with a self-reported positive COVID-19 test. Among US blood donors with serologic evidence of SARS-CoV-2 infection who completed a survey, 47.7% reported an associated self-reported positive COVID-19 test. This proportion changed from July-December 2020 (44.9%) to July-December 2022 (54.8%). This study suggests many SARS-CoV-2 infections in adults are not diagnosed with a test.
Keywords: COVID-19; SARS-CoV-2; antibody assay; blood donors; viral tests.